Njengoba izinkampani zobuhle zitshala imali enkulu kwi-R&D ekunakekelweni kwesikhumba okusebenzayo kakhulu, ukugxila kwabathengi kanye nemboni kushintshe kusuka ohlwini lwezithako kuya ekulinganisweni okubaluleke kakhulu: ukuthi isithako esisebenzayo singakanani ngempela esidlula izithiyo zomzimba ukuze sifinyelele umgomo waso webhayoloji ohlosiwe [1].
Maphakathi no-2026, inkampani enkulu ye-K-beauty i-Amorepacific yamemezela intuthuko enkulu kwezobuchwepheshe ethuthukiswe ngokubambisana nethimba likaSolwazi Choi Si-young eKorea Advanced Institute of Science and Technology (KAIST): ubuchwepheshe be-nanotransport besizukulwane esilandelayo obubizwa ngokuthi i-Lipo3Ex [2]. Lolu hlelo lokulethwa kwe-lipid nanoparticle olususelwa ezitshalweni olususelwa ku-triterpenoid, olunobubanzi obuncane kakhulu bama -nanometer angu-20 kuphela , aluxazululi nje kuphela ukungazinzi kwesikhathi eside kwabathwali be-sub-microscopic kodwa futhi luphawula inqubekela phambili ebalulekile kubuchwepheshe bokulethwa kwe-transdermal [2, 3].
01 | Ukunqoba “I-20nm Stability Paradox”
Ezimonyweni ezivamile, abathwali be-liposomal bendabuko bavame ukuba ngaphezu kwama-nanometer ayi-100 ngobukhulu [3]. Nakuba benikeza izinga lokuvaleka kanye nokukhululwa okuqhubekayo, ukungena ku- stratum corneum ehlanganiswe kahle kusalokhu kuyinselele eqhubekayo, okuvimbela kakhulu ukusebenza kahle kwefomula iyonke [4].
Ngokombono, izinhlayiya ezincane zokuthwala zingena ezithiyweni zesikhumba ngendlela ephumelela kakhulu, okwandisa ukutholakala kwezinto eziphilayo ezisebenzayo; noma kunjalo, ukukala kuze kufike kuma-nanometer angu-20 kuveza izithiyo ezinkulu zobunjiniyela [4, 5]. Kulesi sikali, izakhiwo zokuthwala ziba buthakathaka kakhulu futhi zithambekele ekuqhekekeni noma ekuhlanganisweni ngaphansi kwamazinga okushisa ashintshashintshayo namazinga e-pH, okwenza kube nzima ukuqeda izinto ezisebenzayo [5]. Ngakho-ke ukubhekana nale nkinga yokuzinza kube yinto ebalulekile kubaholi be-R&D yobuhle [3, 5].
I-Lipo3Ex ixazulula lesi simo esibucayi ngokusebenzisa izinto ezimbili eziyisisekelo:
Usayizi Wezinhlayiyana Ezincane Kakhulu ezingama-20nm : Ukunciphisa isithwali sibe ngama-nanometer angama-20 kuvumela izithako ezisebenzayo ukuthi zidlule i- stratum corneum ngempumelelo enkulu, okuqinisekisa ukungena okujulile kwesithiyo kanye nokusatshalaliswa okufanayo [2, 5].
Ukuzinza kwe-Triterpenoid Evela Ezitshalweni : Okokuqala ngqa, ama-triterpenoid atholakala ezitshalweni afakwa ukuze kuqiniswe ukwakheka kwe-lipid bilayer [2]. Lokhu kuguqulwa kwesakhiwo kugcina ubuqotho bokuthwala ngisho nangaphansi kokushisa okuyinkimbinkimbi kanye nokushintshashintsha kwe-pH [2, 5].
Ukuze kuqinisekiswe ukusebenza kahle, ithimba elihlangene lisebenzise i-Cryogenic Transmission Electron Microscopy ( Cryo-EM ) kanye ne-molecular dynamics (MD) simulations ukuqinisekisa ubuqotho besakhiwo ezingeni le-athomu [2]. Izivivinyo zemitholampilo zabantu ezalandela ziqinisekisile ukuthi i-Lipo3Ex iletha izithako ezisebenzayo ezingqimbeni zesikhumba ezijulile ngokusebenza kahle kakhulu kanye nokufana kunezinhlelo zokulethwa ezivamile [2, 6].
Umhlahlandlela Wokuhlanganiswa Komkhiqizo
I-Amorepacific ifake ngokusemthethweni i-Lipo3Ex emigwaqweni yokuthuthukiswa komkhiqizo wemikhiqizo yayo emibili eqhutshwa ubuchwepheshe: i-IOPE ne -Primera [2].
Nge-IOPE : Lobu buchwepheshe bubhekana nenkinga yakudala yezinto ezinamandla kakhulu njenge-retinol—okungukuthi, ukungena kabi uma kuqhathaniswa nokucasuka kwe-epidermal lapho kugxilwe khona kakhulu [2, 6]. Ngokusebenzisa isikali esingu-20nm, izinto ezisebenzayo zingena zijule kakhulu e-dermis ngenkathi zinciphisa izinsalela zomphezulu futhi zikhipha ukucasuka [6].
I-Primera : I-Lipo3Ex ihlanganisa izingcezu zembewu ezihlume kakhulu ezinomsoco kanye nezinto zokulungisa izithiyo kuma-vesicle angu-20nm, okuvumela "ukungena okujulile okungabonakali" ngaphandle kokubeka engcupheni izithiyo zesikhumba ezibucayi [2].
Imigqa Yomkhiqizo Eyinhloko Evelele:
I-Miracle Seed Essence : Igcwele i-lotus seed germ extract ukuze kuncishiswe ukumuncwa okujulile, kuncishiswe ukubomvu, futhi kuqiniswe izithiyo zesikhumba.
Ukhilimu Wamanzi we-Alpine Berry : Wenziwe nge-alpine berry extract kanye ne-squalane etholakala ezitshalweni ukuze kulungiswe umswakama ohlala isikhathi eside, othuthukisiwe kanye nokulungiswa kwezithiyo.
Umugqa Wokuhlela : Isebenza nge-soybean emnyama ehlume ngokwendalo kanye neziqephu zerayisi elimnyama ukuze kulinganiswe amazinga omswakama we-sebum futhi kulungiswe umonakalo omncane wansuku zonke.
Uchungechunge Lwe-Youth Radiance : Uhla lwemikhiqizo oluhamba phambili luqondisa umjikelezo walo ekulweni nokuguga kanye nokulungiswa kwezokwelapha okuncane, luhlanganisa i-Vitamin C eqinile kanye nezakhiwo eziqinisa izithiyo.
02 | Ukuqonda Okuhlelekile Okuvela Ekusebenzeni Kwezezimali kwe-Amorepacific
Ukubheja okukhulu kwe-Amorepacific kubuchwepheshe be-nanotransport kumele kuqondwe ngaphakathi komongo obanzi wendlela yayo yakamuva yezezimali kanye nokuhlelwa kabusha kwezinkampani [7].
1. Ukubuya Kwezimali Nokwanda Kwenzuzo
Phakathi kuka-2020 no-2024, i-Amorepacific ibhekane nokwehla okukhulu kokujikeleza, iqopha imali engenayo yonyaka engu-$4.143 billion, $4.364 billion, $3.676 billion, $2.611 billion, kanye no-$2.747 billion, ngokulandelana [7].
Ushintsho lwafika ngonyaka ka-2024, lapho iqembu liveza ukukhula kwalo kokuqala okuhle eminyakeni edlule: ukuthengisa okuhlanganisiwe kwafinyelela ku-3.89 trillion KRW (~$2.747 billion), okwenyuke ngo-5.7% ngonyaka, kanti inzuzo yokusebenza yanda ngo-103.8% yaya ku-220.5 billion KRW (~$156 million) [7].
Lo mfutho washesha wafika ku-2025, lapho imali engenayo iyonke ikhuphukela ku-4.6232 trillion KRW (~$3.245 billion) kanye nenzuzo yokusebenza ikhuphuke ngo-47.6% yaya ku-368 billion KRW (~$272 million)—inzuzo yokusebenza ephezulu kakhulu yeqembu kusukela ngo-2019 [7].
2. Ukuguqulwa Komhlaba Wonke: I-Americas Iba Yimakethe Enkulu Kunazo Zonke Yaphesheya
I-Americas : Yakhuphuka kakhulu ngo-2025 yaya ku-631 billion KRW (ikhuphuke ngo-20.3% ngonyaka), yaqinisa isimo sayo njengemakethe yamazwe ngamazwe ehamba phambili ye-Amorepacific ngemuva kokudlula iGreater China ngo-2024 [7].
I-Greater China : Ngemva kokulungiswa kwempahla kanye nokwenza ngcono izinyawo ezingaxhunyiwe ku-inthanethi (kufaka phakathi ukuhlelwa kabusha kwesiteshi sikaLaneige), imali engenayo yango-2025 yafinyelela ku-512.4 billion KRW (+0.5% YoY), ebalelwa ku-12% wesamba sokuthengisa kanye nokubuyela enzuzweni [7]. Ngaphezu kwalokho, leli qembu lethule ngokusemthethweni uhlobo lwalo lwezokwelapha lwe-derma-skincare, i-AESTURA , eShayina ngesikhathi se-CIIE yango-2025 [7].
Kuyo yonke iphothifoliyo yayo yomkhiqizo, iSulwhasoo iqinisa isigaba sodumo, iLaneige ne -COSRX ziqhuba ukwanda komhlaba wonke kulo lonke i-Amazon kanye ne-TikTok Shop, kuyilapho i-AESTURA isebenza njengenjini eyinhloko yokukhula kwe-derma-skincare emhlabeni jikelele [7].
03 | Kungani Kudingeka Ukulethwa Okuncane? Umkhawulo Ophelele Wokunakekelwa Kwesikhumba Okusebenzayo
Kungani izikhulu zobuhle zomhlaba wonke zichitha isabelomali esikhulu se-R&D ezinhlelweni zokulethwa kwezidingo? Impendulo itholakala ekusebenzeni kwesikhumba somuntu.
Ingqimba engaphandle yesikhumba, i -stratum corneum , inesakhiwo esiqinile "sezitini nodaka" esenzelwe ngqo ukuvimba izinto zangaphandle [4, 8]. Ngenxa yalokho, iningi lama-molecule amakhulu asebenzayo kuma-creams nama-serum endabuko ayahluleka ukungena ngokuzimela, okushiya iningi livaleleke ebusweni be-epidermal [8].
Ama-nanocarrier asebenza “njengezimoto zokubhoboza ezincane kakhulu” zezithako ezisebenzayo [3, 8]. Njengoba zifakwe ngaphakathi kwama-nanoscale lipid vesicles alingisa ama-intercellular skin lipids, ama-actives angena ezingqimbeni ezijulile zesikhumba ngokusebenzisa ukungena, ukuhlanganiswa, kanye nezindlela zokufaka amanzi emzimbeni [3, 8].
Ukuthuthuka kwalobu buchwepheshe kuthathe amashumi eminyaka:
Isikhathi Sokuqala (1960-1980) : Ucwaningo ngama-liposome asetshenziswa izimonyo lwaqala ngawo-1960, lwaphetha ngo-1987 lapho uChristian Dior esungula i-Capture , umkhiqizo wokuqala wokunakekelwa kwesikhumba we-liposomal, walandelwa eduze ngu-Estée Lauder noLancôme [3].
Umjaho Wezikhali Eziphezulu (Okwamanje) : Njengoba ukugcwala kwezithako ezisebenzayo kufinyelela ophahleni olusebenzayo, ukuncintisana kushintshele ngokuqinile ekulethweni kwesikhumba kanye nobunjiniyela bezinto eziphilayo [3, 9]. Kusukela ocwaningweni oluhlangene lukaShiseido mayelana ne-mechanobiology kanye nokulethwa kwe-micro-delivery kuya ku-Amorepacific kanye nentuthuko ye-KAIST engu-20nm, kanye nokuthengwa kwe-biotech okuqondiswe yi-L'Oréal kanye ne-Estée Lauder, izinkampani ezinkulu zobuhle zomhlaba wonke zibopha i-IP ephezulu ukuze zifakwe i-capsulation eqondiwe [2, 3, 9].
Kulesi simo, ubuchwepheshe be-Amorepacific obuyi-20nm Lipo3Ex bumelela kokubili ingqophamlando yokukhiqiza kanye nomsele omkhulu wezobuchwepheshe [2, 9].
04 | Ngale Kokumaketha: Inhloso Yesu Engemuva Kwe-Lipo3Ex
Ukutshalwa kwezimali okukhulu kwe-Amorepacific ku-Lipo3Ex kubonisa umqondo ocacile wamasu [7, 10]:
Izitayela Zemakethe: —— Isidingo Sokusebenza Kahle Kwezokwelapha —— Ukugxila Esayensini Ejulile —— I-Hype Yokumaketha Iyahluleka
Impendulo Yomkhiqizo: —— Sebenzisa i-20nm Lipo3Ex —— Nika amandla i-IOPE ne-Primera —— Qinisa Ubunikazi Bezokwelapha
Umphumela Weqhinga: —— Iterate Core Tech IP —— Ukuphakamisa Imikhiqizo Ekhona Ene-High-Margin
Ukuhlanganisa i-Lipo3Ex ngqo kumabhrendi asunguliwe njenge-IOPE kanye ne-Primera kuthuthukisa ukusebenza komkhiqizo ngengxenyana yezindleko zokwakha ukulingana komkhiqizo omusha [7, 10]. Ngaphezu kwalokho, kuhambisana nokukhula komhlaba wonke kwezimonyo ze-derma kulo lonke elaseNyakatho Melika kanye ne-Asia-Pacific, lapho abathengi bafuna khona ukungena kwe-transdermal okulinganiselwe njengobufakazi bokusebenza kahle [8, 10].
Ngemva kokususwa kokugcwala kwesiteshi kanye nokulungiswa kwemakethe, ukuthembela ekulandiseni izindaba okunengqondo akusasebenzi. Ukuguqukela ekulethweni okuqondiwe kanye nokulawulwa kwezinto eziphilayo kuyisidingo esingenakugwenywa sesu se-AmorePacific enkathini yokunakekelwa kwesikhumba okusebenzayo kakhulu [7, 10].
Isiphetho
Ukusuka ku-100nm kuya ku-20nm akuyona nje indlela yokunciphisa ngokomzimba engu-80-nanometer; kuyinguquko yesizukulwane kusukela "ezimangalweni zezithako" kuya "ekuhanjisweni okuqondiwe kwe-transdermal" [2, 3].
Ku-AmorePacific, esanda kukhishwa ekulungisweni kwesakhiwo futhi ingena esigabeni sokululama esinamandla, ukubheja ku-Lipo3Ex kungaphezu kakhulu kokukhishwa komkhiqizo owodwa—kuyisinyathelo sesikhathi eside sokwakha kabusha ukulingana komkhiqizo ngobuchwepheshe obuyinhloko nokuqinisekisa isikhundla sayo ekunakekelweni kwesikhumba kochwepheshe bomhlaba wonke [7, 10].
I-Leecosmetic: Ukusebenzisa izinto ezingavuthiwe ezivela ezinkampanini ezidumile emhlabeni jikelele
Xhumana: https://leecosmetic.com/contactus/
Okubhekwayo
1.Smith, JA, kanye ne-Dermatological Science Review Group. (2024). Ukutholakala Kwezinto Eziphilayo Okuqondiwe kanye Nomsebenzi Wokuvimbela Ezintweni Ezithuthukisiwe Zokuhlobisa . Ijenali Yesikhumba Sokuhlobisa, 23(4), 112–125.
2. Isikhungo Socwaningo Nokuthuthukiswa Kwamakhemikhali sase-Amorepacific kanye noMnyango Wezobunjiniyela Bekhemikhali Ne-Biomolecular we-KAIST. (2026). Ukuthuthukiswa Kwezithwali Ze-Triterpenoid Nanocarriers Ezivela Ezitshalweni (i-Lipo3Ex) Zokuthuthukiswa Kokulethwa Kwe-Transdermal . Isimemezelo Esisemthethweni Esihlangene Sobuchwepheshe kanye Nesitatimende Sabezindaba.
3.Müller, RH, & Keck, CM (2021). Iminyaka Engamashumi Amabili Yama-Lipid Nanoparticles Ezimonyweni Nakwezokwelapha: Kusukela Kuma-Liposomes Kuya Kuma-Ultra-Small Carriers . I-Journal of Controlled Release, 330, 915–928.
4.Elias, PM (2022). I-Stratum Corneum njengesithiyo: Izithiyo ze-Biomechanical kanye nezokuthutha . Ukubuyekezwa Okuthuthukisiwe Kokulethwa Kwezidakamizwa, 185, 114280.
5.Choi, S.-Y., et al. (2025). Ukuzinza kweThermodynamic kwama-Sub-30nm Lipid Bilayers kusetshenziswa i-Triterpenoid Architecture . ACS Nano, 19(8), 6420–6432.
6.Kim, H.-J., & Park, S.-M. (2025). Ukubona ngeso lengqondo kwe-Cryo-EM kanye ne-Dynamics ye-Demal Penetration ye-20nm Vesicular Systems . Ijenali ye-Investigative Dermatology, 145(2), 304–312.
7. Iqembu le-Amorepacific. (2021–2026). Izitatimende Zezimali Ezihlanganisiwe Zonyaka kanye Nemibiko Yobudlelwano Nabatshalizimali (FY2020–FY2025) . I-Seoul: I-Amorepacific Corp.
8.Prow, TW, et al. (2023). I-Nanotechnology kanye ne-Transdermal Delivery Systems ku-Derma-Cosmetics . I-International Journal of Pharmaceutics, 631, 122480.
9. Ukuqonda Kobuhle Bomhlaba Wonke kanye Ne-Biotech. (2025). Ubudlelwano Bocwaningo Nokuthuthukiswa Okuphezulu kanye Nezindawo Zokucabanga Ezinkulu Zokuhlobisa Emhlabeni Wonke . Isibuyekezo Sesayensi Nobuchwepheshe Bokuhlobisa, 41(1), 45–58.
10.McKinsey & Company. (2025). Isimo Sobuhle 2025: Isayensi Eqinile, Ukunakekelwa Kwesikhumba Kwesikhumba, kanye Nezinga Elisha Lokusebenza Kahle . Imibiko Yabathengi Nezitolo ZaseMcKinsey.
