Raws li cov koom haum kev zoo nkauj nqis peev ntau rau hauv R&D rau hauv kev saib xyuas tawv nqaij zoo, kev tsom mus rau cov neeg siv khoom thiab kev lag luam tau hloov pauv ntawm cov npe khoom xyaw mus rau qhov ntsuas tseem ceeb dua: ntau npaum li cas ntawm cov khoom xyaw nquag yeej hla dhau cov teeb meem lub cev kom mus txog nws lub hom phiaj tseem ceeb [1].
Thaum nruab nrab xyoo 2026, K-beauty loj Amorepacific tau tshaj tawm txog kev tshawb pom tseem ceeb hauv kev siv tshuab los ntawm kev koom tes nrog pab pawg ntawm Professor Choi Si-young ntawm Korea Advanced Institute of Science and Technology (KAIST): ib tiam tshiab ntawm nanotransport technology hu ua Lipo3Ex [2]. Lub tshuab xa khoom lipid nanoparticle uas yog los ntawm cov nroj tsuag no, nrog rau lub cheeb me me ntawm tsuas yog 20 nanometers , tsis yog tsuas yog daws qhov teeb meem tsis ruaj khov ntawm cov neeg nqa khoom sub-microscopic xwb tab sis kuj yog ib qho kev dhia mus rau pem hauv ntej hauv kev siv tshuab xa khoom transdermal [2, 3].
01 | Kov yeej qhov "20nm Stability Paradox"
Hauv cov tshuaj pleev ib ce ib txwm muaj, cov liposomal nqa khoom ib txwm muaj qhov loj tshaj 100 nanometers [3]. Txawm hais tias lawv muab qib encapsulation thiab kev tso tawm tas mus li, kev nkag mus rau hauv cov stratum corneum uas nruj nreem tseem yog qhov kev sib tw tas mus li, ua rau muaj kev txwv tsis pub siv cov mis tshuaj tag nrho [4].
Hauv kev xav, cov khoom me me nkag mus rau hauv daim tawv nqaij kom zoo dua, ua kom muaj kev nyab xeeb ntau dua; txawm li cas los xij, kev txo qis mus rau 20 nanometers ua rau muaj kev cov nyom loj heev [4, 5]. Ntawm qhov ntsuas no, cov qauv nqa khoom ua rau tsis muaj zog thiab yooj yim tawg lossis sib sau ua ke hauv qab qhov kub thiab pH hloov pauv, ua rau cov tshuaj sib xyaw ua haujlwm tsis muaj zog [5]. Kev daws qhov teeb meem kev ruaj khov no tau dhau los ua qhov nyuaj rau cov thawj coj R&D kev zoo nkauj [3, 5].
Lipo3Ex daws qhov teeb meem no los ntawm ob qho kev tsim kho tshiab:
20nm Ultra-Small Particle Size : Kev txo qhov carrier mus rau 20 nanometers tso cai rau cov khoom xyaw nquag hla lub stratum corneum zoo dua, ua kom muaj kev nkag mus tob dua thiab kev faib tawm sib npaug [2, 5].
Kev Ruaj Ntseg Triterpenoid Los Ntawm Cov Nroj Tsuag : Thawj zaug, cov triterpenoids los ntawm cov nroj tsuag tau koom ua ke los txhawb cov qauv lipid bilayer [2]. Qhov kev hloov kho qauv no tswj kev ruaj khov ntawm cov cab kuj txawm tias nyob hauv qhov kub thiab txias thiab pH hloov pauv [2, 5].
Txhawm rau kom paub tseeb tias kev ua tau zoo, pab pawg sib koom ua ke tau siv Cryogenic Transmission Electron Microscopy ( Cryo-EM ) thiab molecular dynamics (MD) simulations los lees paub qhov kev ncaj ncees ntawm qib atomic [2]. Cov kev sim tshuaj hauv tib neeg tom qab ntawd tau lees paub tias Lipo3Ex xa cov khoom xyaw nquag mus rau hauv cov khaubncaws sab nraud povtseg tob dua nrog kev ua haujlwm zoo dua thiab kev sib xws dua li cov txheej txheem xa khoom ib txwm muaj [2, 6].
Daim Ntawv Qhia Txog Kev Sib Koom Ua Khoom
Amorepacific tau koom ua ke Lipo3Ex rau hauv cov kav dej tsim khoom ntawm nws ob lub npe nrov uas siv thev naus laus zis: IOPE thiab Primera [2].
Rau IOPE : Cov thev naus laus zis daws qhov teeb meem ntawm cov tshuaj muaj zog heev xws li retinol—uas yog, kev nkag mus tsis zoo piv rau kev khaus ntawm daim tawv nqaij ntawm qhov ntau [2, 6]. Los ntawm kev siv qhov ntsuas 20nm, cov tshuaj nquag nkag mus tob dua rau hauv daim tawv nqaij thaum txo cov seem ntawm qhov chaw thiab kev khaus ntawm daim tawv nqaij [6].
Rau Primera : Lipo3Ex muab cov noob uas muaj ntau yam khoom noj khoom haus thiab cov khoom kho kom zoo rau hauv 20nm vesicles, ua rau tsis muaj teeb meem, "nkag mus tob" yam tsis cuam tshuam rau cov tawv nqaij mos [2].
Cov Kab Khoom Tseem Ceeb Tshaj Plaws:
Miracle Seed Essence : Muaj cov kua txiv ntawm cov noob paj noob hlis ua kom cov tawv nqaij noo, txo qhov liab, thiab ua kom daim tawv nqaij ruaj khov.
Alpine Berry Watery Cream : Tsim los ntawm alpine berry extract thiab squalane los ntawm cov nroj tsuag rau kev noo noo ntev thiab kho qhov teeb meem.
Kab Organience : Ua los ntawm cov organic germinated dub taum pauv thiab dub mov extracts los sib npaug sebum-moisture theem thiab kho txhua hnub micro-puas tsuaj.
Cov Koob Tshuaj Rau Cov Hluas Ci Ntxim Hlub : Cov kab tshuaj zoo tshaj plaws uas tsav nws txoj kev hloov mus rau kev tiv thaiv kev laus thiab kev kho mob, kev sib xyaw ua ke ntawm Vitamin C ruaj khov nrog cov tshuaj sib xyaw ua ke uas txhawb nqa kev thaiv.
02 | Kev Nkag Siab Txog Kev Ua Lag Luam Los Ntawm Amorepacific Txoj Kev Ua Tau Zoo Nyiaj Txiag
Amorepacific qhov kev twv txiaj loj rau nanotransport thev naus laus zis yuav tsum tau nkag siab hauv cov ntsiab lus dav dav ntawm nws txoj kev nyiaj txiag tsis ntev los no thiab kev hloov kho dua tshiab ntawm cov tuam txhab [7].
1. Kev Rov Qab Zoo Dua Nyiaj Txiag thiab Kev Ua Tau Nyiaj Ntau Ntxiv
Nruab nrab xyoo 2020 thiab 2024, Amorepacific tau ntsib kev poob qis ntawm lub voj voog, sau cov nyiaj tau los txhua xyoo ntawm $ 4.143 billion, $ 4.364 billion, $ 3.676 billion, $ 2.611 billion, thiab $ 2.747 billion, raws li [7].
Lub sijhawm hloov pauv tau los txog rau xyoo FY2024, thaum pawg neeg tau tshaj tawm nws thawj qhov kev loj hlob zoo hauv xyoo: kev muag khoom sib koom ua ke tau txog 3.89 trillion KRW (~ $ 2.747 billion), nce 5.7% YoY, thaum cov nyiaj tau los ntawm kev ua haujlwm tau nce 103.8% mus rau 220.5 billion KRW (~ $ 156 lab) [7].
Lub zog no tau nce mus txog xyoo 2025, nrog rau tag nrho cov nyiaj tau los nce mus txog 4.6232 trillion KRW (~ $ 3.245 billion) thiab cov nyiaj tau los ntawm kev ua haujlwm nce 47.6% mus txog 368 billion KRW (~ $ 272 lab) - qhov nyiaj tau los ntawm kev ua haujlwm siab tshaj plaws txij li xyoo 2019 [7].
2. Kev Hloov Kho Thoob Ntiaj Teb: Tebchaws Asmeskas Ua Lag Luam Txawv Tebchaws Loj Tshaj Plaws
Tebchaws Asmeskas : Tau nce siab heev hauv xyoo 2025 txog 631 billion KRW (nce 20.3% YoY), ua kom nws lub npe nrov ua Amorepacific lub khw thoob ntiaj teb tom qab dhau Greater China hauv xyoo 2024 [7].
Tuam Tshoj Loj : Tom qab kev txiav txim siab txog cov khoom muag thiab kev txhim kho qhov chaw offline (suav nrog Laneige txoj kev hloov kho channel), cov nyiaj tau los xyoo 2025 tau txog 512.4 billion KRW (+ 0.5% YoY), suav txog 12% ntawm tag nrho cov muag khoom thiab rov qab los ua kom tau txiaj ntsig [7]. Tsis tas li ntawd, pawg neeg tau tshaj tawm nws lub npe kho mob derma-skincare, AESTURA , rau Tuam Tshoj thaum lub sijhawm 2025 CIIE [7].
Thoob plaws nws cov khoom lag luam, Sulwhasoo yog lub hauv paus ntawm qhov kev lag luam muaj koob npe nrov, Laneige thiab COSRX tsav kev nthuav dav thoob ntiaj teb thoob plaws Amazon thiab TikTok Shop, thaum AESTURA ua lub cav tseem ceeb rau kev loj hlob ntawm kev saib xyuas tawv nqaij thoob ntiaj teb [7].
03 | Vim li cas thiaj xaiv Nano-Delivery? Qhov kawg ntawm kev saib xyuas tawv nqaij
Vim li cas cov tuam txhab zoo nkauj thoob ntiaj teb thiaj li siv nyiaj ntau heev rau kev tshawb fawb thiab kev txhim kho (R&D) rau hauv cov txheej txheem xa khoom? Cov lus teb yog nyob rau hauv tib neeg daim tawv nqaij lub cev.
Txheej sab nraud tshaj plaws ntawm daim tawv nqaij, stratum corneum , muaj cov qauv "brick-and-mortar" uas tau ntim nruj nreem tsim los thaiv cov khoom txawv teb chaws [4, 8]. Yog li ntawd, feem ntau cov tshuaj loj hauv cov tshuaj pleev ib txwm thiab cov tshuaj serum tsis tuaj yeem nkag mus rau hauv nws tus kheej, ua rau feem ntau ntawm cov khoom poob rau ntawm qhov chaw epidermal [8].
Cov Nanocarriers ua haujlwm ua "cov tsheb khawb me me" rau cov khoom xyaw nquag [3, 8]. Encapsulated hauv nanoscale lipid vesicles uas ua raws li cov lipids ntawm daim tawv nqaij, cov khoom nquag nkag mus rau hauv cov khaubncaws sab nraud povtseg tob dua los ntawm kev nkag mus, kev sib xyaw, thiab cov txheej txheem hydration [3, 8].
Kev hloov pauv ntawm cov thev naus laus zis no kav ntev li ntau xyoo:
Lub Caij Pib (1960s–1980s) : Kev tshawb fawb txog cov liposomes siv rau cov tshuaj pleev ib ce tau pib xyoo 1960s, xaus rau xyoo 1987 thaum Christian Dior tau tsim Capture , thawj cov khoom siv kho mob liposomal, ua raws li Estée Lauder thiab Lancôme [3].
Kev Sib Tw Ntaus Caj Npab Sab Sauv (Tam Sim No) : Raws li cov khoom xyaw nquag ua haujlwm ncav cuag qhov ua tau zoo, kev sib tw tau hloov pauv mus rau kev xa khoom transdermal thiab bioengineering [3, 9]. Los ntawm Shiseido txoj kev tshawb fawb ua ke ntawm mechanobiology thiab micro-delivery mus rau Amorepacific thiab KAIST qhov kev tawg 20nm, nrog rau kev yuav khoom biotech zoo los ntawm L'Oréal thiab Estée Lauder, cov tuam txhab kev zoo nkauj thoob ntiaj teb tab tom xauv rau hauv IP sab saud rau kev encapsulation tsom [2, 3, 9].
Hauv qhov xwm txheej no, Amorepacific's 20nm Lipo3Ex thev naus laus zis sawv cev rau ob qho tib si lub hauv paus tseem ceeb ntawm kev tsim khoom thiab lub hauv paus thev naus laus zis loj heev [2, 9].
04 | Dhau Kev Lag Luam: Qhov Tseem Ceeb ntawm Lipo3Ex
Amorepacific txoj kev nqis peev ntau hauv Lipo3Ex qhia txog kev xav zoo meej [7, 10]:
Cov Qauv Lag Luam: —— Kev Xav Tau Kev Ua Haujlwm Zoo Hauv Kev Kho Mob —— Kev Tsom Mus Rau Kev Tshawb Fawb tob —— Kev Lag Luam Hype Tsis Ua Haujlwm
Cov Lus Teb ntawm Hom Lag Luam: —— Siv 20nm Lipo3Ex —— Txhawb IOPE & Primera —— Ua Kom Muaj Kev Txheeb Ze Hauv Kev Kho Mob
Cov Txiaj Ntsig Zoo: —— Rov Ua Dua Core Tech IP —— Txhawb Cov Hom Lag Luam Uas Muaj Peev Xwm Loj
Kev koom ua ke Lipo3Ex ncaj qha rau hauv cov npe lag luam uas tau tsim tsa zoo li IOPE thiab Primera txhim kho kev ua tau zoo ntawm cov khoom ntawm ib feem ntawm tus nqi ntawm kev tsim cov khoom lag luam tshiab [7, 10]. Ntxiv mus, nws sib haum nrog kev vam meej thoob ntiaj teb hauv kev kho mob tawv nqaij thoob plaws North America thiab Asia-Pacific, qhov twg cov neeg siv khoom xav tau kev nkag mus rau hauv daim tawv nqaij raws li pov thawj ntawm kev ua tau zoo [8, 10].
Tom qab kev txo qis ntawm cov channel thiab kev hloov kho dua tshiab ntawm kev ua lag luam, kev cia siab rau kev piav dab neeg tsis muaj txiaj ntsig lawm. Kev tig mus rau kev xa khoom thiab kev tswj hwm biomechanical yog qhov tseem ceeb rau Amorepacific hauv lub sijhawm ntawm kev saib xyuas tawv nqaij zoo [7, 10].
xaus
Tsiv ntawm 100nm mus rau 20nm tsis yog tsuas yog 80-nanometer lub cev txo qis xwb; nws yog kev hloov pauv ntawm tiam neeg los ntawm "cov lus thov khoom xyaw" mus rau "kev xa khoom transdermal" [2, 3].
Rau Amorepacific, tshiab tawm ntawm kev hloov kho tshiab thiab nkag mus rau theem rov zoo, kev twv rau Lipo3Ex yog ntau tshaj li ib qho khoom tso tawm - nws yog kev txav mus los ntev los tsim kho lub npe lag luam los ntawm cov thev naus laus zis tseem ceeb thiab ruaj ntseg nws txoj haujlwm hauv kev saib xyuas tawv nqaij thoob ntiaj teb [7, 10].
Leecosmetic: Siv cov ntaub ntawv raw los ntawm cov tuam txhab nto moo thoob ntiaj teb
Hu rau: https://leecosmetic.com/contactus/
References
1. Smith, JA, & Dermatological Science Review Group. (2024). Lub Hom Phiaj Bioavailability thiab Barrier Function hauv Advanced Cosmeceuticals . Journal of Cosmetic Dermatology, 23(4), 112–125.
2. Amorepacific R&D Center & KAIST Department of Chemical and Biomolecular Engineering. (2026). Kev Tsim Kho Cov Tshuaj Triterpenoid Nanocarriers Uas Tau Los Ntawm Cov Nroj Tsuag (Lipo3Ex) Rau Kev Xa Khoom Zoo Dua Transdermal . Kev Tshaj Tawm Txog Kev Ua Haujlwm Sib Koom Tes & Xov Xwm Tshaj Tawm.
3. Müller, RH, & Keck, CM (2021). Nees nkaum xyoo ntawm Lipid Nanoparticles hauv cov tshuaj pleev ib ce thiab kev kho mob: Los ntawm Liposomes mus rau Ultra-Small Carriers . Phau ntawv xov xwm ntawm Kev Tso Tawm Tswj, 330, 915–928.
4. Elias, PM (2022). Lub Stratum Corneum ua ib qho Barrier: Biomechanical thiab Transport Constraints . Advanced Drug Delivery Reviews, 185, 114280.
5.Choi, S.-Y., et al. (2025). Kev Ruaj Ntseg Thermodynamic ntawm Sub-30nm Lipid Bilayers Siv Triterpenoid Architecture . ACS Nano, 19(8), 6420–6432.
6. Kim, H.-J., & Park, S.-M. (2025). Cryo-EM Visualization thiab Dermal Penetration Dynamics ntawm 20nm Vesicular Systems . Journal of Investigative Dermatology, 145(2), 304–312.
7. Amorepacific Group. (2021–2026). Cov Lus Qhia Txog Nyiaj Txiag Txhua Xyoo thiab Cov Ntawv Qhia Txog Kev Sib Raug Zoo Nrog Cov Tub Ua Lag Luam (FY2020–FY2025) . Seoul: Amorepacific Corp.
8. Prow, TW, et al. (2023). Nanotechnology thiab Transdermal Delivery Systems hauv Derma-Cosmetics . International Journal of Pharmaceutics, 631, 122480.
9. Kev Nkag Siab Txog Kev Zoo Nkauj Thoob Ntiaj Teb & Biotech. (2025). Kev Koom Tes R&D Sab Sauv thiab Cov Khoom Siv Txawj Ntse hauv Cov Tuam Txhab Loj Thoob Ntiaj Teb . Kev Tshuaj Xyuas Kev Tshawb Fawb Txog Kev Zoo Nkauj & Tshuab, 41(1), 45–58.
10. McKinsey & Company. (2025). Lub Xeev ntawm Kev Zoo Nkauj Xyoo 2025: Kev Tshawb Fawb Txog Kev Siv Tshuaj Kho Mob Tawv Nqaij, thiab Tus Qauv Tshiab Txog Kev Siv Tshuaj Zoo . McKinsey Cov Ntaub Ntawv Txog Cov Neeg Siv Khoom & Kev Muag Khoom.
