Thaum Lub Kaum Hli 1, 2026, lub tuam txhab biotech Fabkis AFYREN (Euronext: ALAFY) tau tshaj tawm tias nws koom tes nrog South African microbiome skincare hom Esse Skincare los tsim Barrier Rescue, ib qho tshuaj pleev kho qhov teeb meem. Qhov no yog thawj daim ntawv qhia txog kev saib xyuas tawv nqaij hauv ntiaj teb uas muaj fermented, 100% biobased propionic acid ua nws cov khoom xyaw tseem ceeb.
Cov lus tshaj tawm tau raug khaws los ntawm cov chaw lag luam kev zoo nkauj thoob ntiaj teb suav nrog Personal Care Insights , Home & Personal Care Middle East & Africa , The Microbiologist , thiab lub platform xov xwm carbon rov ua dua tshiab Renewable Carbon News.
Cov khoom siv raw muaj daim ntawv pov thawj COSMOS ntuj thiab organic. Qhov kev tso tawm no yog qhov tseem ceeb vim nws hloov pauv ntau xyoo ntawm kev lag luam: propionic acid tau pom ntev los ua ib qho tshuaj preservative hauv cov tshuaj pleev ib ce. Txawm hais tias alpha-hydroxy acids thiab salicylic acid tau lees paub dav dav rau kev exfoliating daim tawv nqaij thiab ua kom cov cell saum npoo av hloov pauv sai dua, propionic acid tam sim no tsis yog tsuas yog ua ib qho tshuaj antimicrobial stabilizer, tab sis ua ib qho khoom xyaw nrog cov txiaj ntsig microbiome tawv nqaij.
Propionic Acid: Ntev suav tias tsuas yog ib qho tshuaj pleev ib ce preservative
Propionic acid yog ib hom roj fatty acid uas muaj peb lub carbon luv luv nrog cov mis molecular C₃H₆O₂, cov qauv CH₃CH₂COOH thiab qhov hnyav molecular yog 74.08. Thaum kub ib puag ncig, nws zoo li cov kua tsis muaj xim nrog lub ntxhiab tsw qab, ua rau nws yooj yim paub. Nws sib xyaw nrog dej tag nrho thiab muaj qhov kub ntawm huab cua li ntawm 141 ° C.
Ua ib qho organic acid, nws cov tshuaj tua kab mob ua haujlwm yog nyob ntawm pH ntau heev. Nyob rau hauv cov xwm txheej acidic, nws xaiv suppresses kev loj hlob ntawm pwm thiab cov kab mob. Vim li no, nws tau siv rau hauv cov zaub mov txawv ua ib qho tshuaj preservative, biocide thiab pH adjuster. Lub EU CosIng database teev nws cov haujlwm zoo nkauj ua antimicrobial, preservative, tshuaj tsw qab thiab pH regulator. Tuam Tshoj National Medical Products Administration (NMPA) Catalog of Used Cosmetic Raw Materials (2021 Edition) txais yuav tib qho kev faib tawm. Tsawg dua ib puas cov khoom siv zoo nkauj raug cai hauv Suav teb muaj propionic acid, thiab feem ntau ntawm cov ntaub ntawv ntawd tau raug tshem tawm txij li thaum.
Kev tshuaj xyuas cov ntaub ntawv thoob ntiaj teb qhia tau tias propionic acid feem ntau tshwm sim hauv cov tshuaj pleev ib ce xim. MAC Studio Fix Soft Matte Foundation Stick thiab Wander Beauty On-The-Glow Blush thiab Illuminator ob qho tib si teev propionic acid rau lub hom phiaj khaws cia. Hauv kev saib xyuas tawv nqaij, cov qauv qub xws li NeoGenesis Salicylic Acid Gel thiab AVON Clearskin Deep Pore Cleansing Scrub ib zaug tau suav nrog cov tshuaj no tsuas yog los tiv thaiv cov khoom kom tsis txhob puas, es tsis yog hloov kho cov kab mob ntawm daim tawv nqaij. Qhov no tsa ib lo lus nug tseem ceeb: yuav ua li cas cov khoom xyaw uas ib txwm siv los tua cov kab mob sib kis thiab txuas lub neej txee kom rov qab tau ua cov khoom kho microbiome? Cov lus teb nyob rau hauv kev nce qib loj hauv kev tshawb fawb thiab kev txhim kho kom zoo nkauj hauv xyoo tas los no.
Vim li cas Propionic Acid tsis tau siv los hloov kho cov kab mob hauv daim tawv nqaij
Puas muaj propionic acid uas pab tau microbiome rau kev saib xyuas tawv nqaij? Tau ntau xyoo, kev lag luam kho kom zoo nkauj tau ua haujlwm raws li kev xav dav dav tias nws cov kev ua haujlwm tua kab mob dav dav tsis sib haum nrog cov ntsiab cai tseem ceeb ntawm microbiome - txawm hais tias qhov no tsis tau txhais hais tias cov molecule tsis muaj peev xwm ua haujlwm tau zoo.
Thaum lub hom phiaj ntawm kev saib xyuas tawv nqaij uas tsom mus rau microbiome tau txais kev txhawb nqa dav dua, cov neeg tsim cov tshuaj pleev ib ce tau pib tshawb nrhiav ntau yam khoom xyaw. Microbiome kev saib xyuas tawv nqaij tsom mus rau kev tswj hwm cov kab mob ntawm daim tawv nqaij kom ruaj khov, txhawb nqa cov kab mob zoo thiab txo cov teeb meem pro-inflammatory.
Thaum siv ua tshuaj preservative, propionic acid muaj peev xwm tiv thaiv tau cov kab mob me me (microbial inhibition) dav dav. Thaum siv cov tshuaj preservative li niaj zaus, nws tsis tuaj yeem paub qhov txawv ntawm cov kab mob pathogenic thiab cov kab mob commensal uas nyob ntawm daim tawv nqaij, ua rau cov kab mob tsis ua haujlwm. Kev tiv thaiv cov kab mob uas tsis xaiv ua rau cov kab mob me me hauv daim tawv nqaij puas tsuaj tag nrho.
Qhov no ua rau muaj kev pom zoo dav dav hauv kev lag luam: cov khoom xyaw uas tsim los rau kev khaws cia cov tshuaj tua kab mob feem ntau tsis haum rau kev kho cov kab mob hauv daim tawv nqaij. Yog li ntawd, kev tshawb fawb thiab kev tsim khoom ntawm cov tshuaj microbiome thaum ntxov feem ntau zam cov kua qaub propionic, nyiam cov kev xaiv uas mos dua suav nrog cov kab mob probiotic uas muaj sia nyob, prebiotics, cov lim dej fermentation tom qab thiab lactic acid.
Dab tsi tau hloov pauv kom siv tau Propionic Acid hauv Microbiome Skincare?
Ib txoj kev tshawb fawb tseem ceeb xyoo 2022 luam tawm hauv Journal of Experimental Medicine tau hloov kho qhov kev nkag siab no, qhia txog lub peev xwm loj rau propionic acid hauv kev tswj hwm cov kab mob ntawm daim tawv nqaij.
Cov kev tshawb fawb no tau ua ke coj los ntawm pab pawg neeg ntawm Xibfwb Wei Li ntawm Tsev Kho Mob Huashan, Fudan University, thiab pab pawg ntawm Xibfwb Xu Yao ntawm Suav Academy of Medical Sciences & Peking Union Medical College Tsev Kho Mob, Lub Tsev Kawm Ntawv ntawm Dermatology. Dr. Zhuoqiong Qiu tau ua tus sau thawj zaug; pab pawg tshawb fawb suav nrog 14 tus kws tshawb fawb xws li Zhulai Zhu thiab Xiaochun Liu. Daim ntawv, hu ua A dysregulated sebum–microbial metabolite–IL-33 axis initiates skin o hauv atopic dermatitis , tau txheeb xyuas sebum–microbial metabolite–IL-33 signalling axis ua tus tsav tsheb tseem ceeb ntawm atopic dermatitis pathogenesis.
Cov pab pawg tshawb fawb tau sau cov qauv tawv nqaij ntawm lub ntsej muag los ntawm cov neeg ua haujlwm pab dawb noj qab haus huv thiab cov neeg mob uas muaj mob atopic dermatitis (AD) rau kev sib piv. Cov neeg mob AD tau pom tias cov roj sebum qis dua thiab txo cov tawv nqaij ntawm cov tshuaj propionate piv rau cov neeg noj qab haus huv. Cov kev tshawb fawb tom qab ntawd siv cov qauv murine AD uas ua rau MC903 ua rau pom tias kev siv tshuaj propionate rau ntawm daim tawv nqaij tau txo qis IL-33 tso tawm los ntawm keratinocytes thiab txo qhov mob ntawm daim tawv nqaij. Cov nyhuv modulatory no ua haujlwm los ntawm kev tswj hwm HDAC2 / 3 thiab kev ua haujlwm ntawm txoj kev xa xov AhR.
Cov pab neeg tau mus ua ib qho kev sim tshuaj me me uas ua pov thawj tias muaj lub tswv yim los nrhiav cov neeg koom nrog uas muaj mob atopic dermatitis me me mus rau nruab nrab. Kev siv cov tshuaj propionate rau ntawm daim tawv nqaij ntawm cov concentration uas cuam tshuam rau lub cev ua rau muaj kev txo qis ntawm cov qhab nia o ntawm qhov txhab, yam tsis ua rau muaj kev cuam tshuam loj lossis kev khaus ntawm cov kab mob me me.
Ib qho xaus lus tseem ceeb los ntawm kev tshawb fawb tsim kom muaj qhov ntsuas meej: qhov ntau npaum li cas thiab kev siv tshuaj tswj hwm cov txiaj ntsig ntawm propionic acid. Thaum siv rau kev khaws cia ntau, propionic acid ua haujlwm ua cov tshuaj tua kab mob dav dav uas tsom mus rau cov kab mob uas ua rau puas tsuaj hauv cov khoom. Thaum siv ua cov tshuaj microbiome nquag, propionate yog cov metabolite uas tshwm sim los ntawm cov kab mob ntawm daim tawv nqaij xws li Cutibacterium acnes . Siv rau qhov tsawg, qhov concentration ntawm lub cev, nws tsis tshem tawm cov kab mob zoo ntawm daim tawv nqaij; hloov chaw, nws pab kho kom daim tawv nqaij zoo li qub.
Hauv kev hais yooj yim, propionic acid ua haujlwm ua "tus xa xov metabolic" hauv daim tawv nqaij microbiome. Nws tus cwj pwm tiv thaiv yog qhov cuam tshuam thib ob uas pom ntawm qhov ntau ntawm cov concentration, thaum nws lub luag haujlwm hauv lub cev hauv daim tawv nqaij yog kev tiv thaiv kev o thiab kev tswj hwm kev thaiv. Ua ntej tsab ntawv tshaj tawm no, kev lag luam kev zoo nkauj tsuas yog tsom mus rau nws lub peev xwm tiv thaiv kab mob thiab tsis quav ntsej nws lub luag haujlwm ua cim.
Tus thawj coj ntawm AFYREN, Nicolas Sordet, tau hais hauv tsab xov xwm tshaj tawm thaum Lub Kaum Ob Hlis 2025 uas tshaj tawm txog kev koom tes: "Qhov no qhia tau hais tias biotechnology tuaj yeem qhib cov cib fim tshiab rau kev ua tau zoo thiab kev ruaj khov hauv cov tshuaj pleev ib ce uas coj cov txiaj ntsig tiag tiag rau tib neeg thiab ib puag ncig. Peb tos ntsoov yuav pom cov khoom thawj zaug ncav cuag cov neeg siv khoom."
Tus Thawj Coj Saib Xyuas Kev Lag Luam ntawm AFYREN, Joachim Merziger, tau hais ntxiv rau hauv xov xwm tom qab Barrier Rescue tshaj tawm tias: "Kev koom tes no qhia tau hais tias biotechnology tuaj yeem qhib cov cib fim tshiab rau kev ua tau zoo thiab kev ruaj khov hauv kev siv tshuaj pleev ib ce, coj cov txiaj ntsig zoo rau tib neeg thiab lub ntiaj teb. Peb zoo siab heev uas pom cov khoom thawj zaug tam sim no ncav cuag cov neeg siv khoom."
Tus tsim Esse Skincare Trevor Steyn tau siv sijhawm ntau tshaj kaum xyoo los tshawb nrhiav txog cov kab mob me me hauv daim tawv nqaij thiab yog ib tus thawj coj hauv kev tawm tswv yim hloov pauv ntawm kev tsim cov tshuaj uas tsom mus rau cov kab mob me me mus rau kev tsim cov tshuaj uas ua rau muaj cov tshuaj metabolite. Hauv kev xam phaj nrog lub tuam txhab, nws piav qhia tias kev tshawb fawb txog cov kab mob me me thaum ntxov tau muab qhov tseem ceeb rau kev siv cov kab mob uas muaj sia nyob, uas ntsib teeb meem loj heev rau kev ruaj khov thiab kev nkag mus rau hauv daim tawv nqaij hauv cov khoom siv pleev kom zoo nkauj. Nws pab neeg txoj haujlwm kos duab cov txheej txheem metabolic ntawm sebum tau qhia tias kev ntxiv cov metabolites uas cov kab mob me me hauv daim tawv nqaij tso tawm, xws li propionic acid, muab txoj hauv kev ncaj qha dua los hloov cov teeb meem inflammatory.
Kev Txhim Kho Sib Npaug Ntawm Cov Neeg Muab Khoom Siv Raw Hauv Suav Teb
Cov chaw tsim khoom xyaw hauv Suav teb kuj tseem tab tom txhim kho txoj haujlwm hauv daim teb no.
Ntawm kev nthuav qhia cov khoom xyaw, Shanghai UniVOOK (Bailuo Hualian Chemical) tau qhia tias nws tau nthuav dav kev tsim khoom ntawm 100% biobased propionic acid uas tau ntawv pov thawj los ntawm SGS, tsim los ntawm kev fermentation microbial. Txawm li cas los xij, raws li Tuam Tshoj txoj cai tswjfwm kev kho kom zoo nkauj, propionic acid tseem raug cais ua cov khoom siv raw preservative. Lub sector ntsib teeb meem sib koom ua ke: cov tshuaj molecule nws tus kheej tsis hloov pauv, tab sis cov hom phiaj tsim thiab R&D cov laj thawj tau rov xav dua. Cov ntawv teev cov khoom siv raw kev cai feem ntau poob qis dua cov kev tshawb pom tshiab txog kev tshawb fawb txog microbiology ntawm daim tawv nqaij.
Ib tug thawj coj saib xyuas kev tshawb fawb thiab kev txhim kho (R&D) ntawm Shandong Hongda Group tau hais lus ntawm lub rooj sib tham txog cov khoom xyaw pleev kom zoo nkauj tias lub tuam txhab tau tsim cov kua qaub propionic uas tau los ntawm cov hmoov pob kws ntev lawm. Keeb kwm, qhov kev thov ntawm cov neeg siv khoom tsuas yog txwv rau kev tiv thaiv pwm thiab kev khaws cia. Nyob rau xyoo tas los no, lub tuam txhab tau txais cov lus nug los ntawm cov npe tshuaj pleev ib ce hauv Suav teb uas xav sim cov kua qaub propionic rau kev kho qhov thaiv thiab cov ntawv thov microbiome, txawm hais tias cov qauv ntsuas kev ua tau zoo rau cov lus thov no tseem tab tom loj hlob.
Kev Cuam Tshuam Dav Dua Hauv Kev Lag Luam Rau Cov Hom Tshuaj Pleev Xim
Kev hloov pauv ntawm Propionic acid los ntawm kev khaws cia mus rau microbiome active qhia txog kev hloov pauv dav dua hauv microbiome skincare R&D, uas nqa cov txiaj ntsig mus sij hawm ntev rau cov lag luam pleev kom zoo nkauj.
Ua ntej, nws qhib ib txoj kev tsim kho tshiab rau cov khoom siv raw uas twb muaj lawm, uas tau teev tseg.
Kev tsim kho tshiab ntawm cov khoom xyaw pleev ib txwm muaj feem ntau yog nyob ntawm kev tshawb pom cov molecules tshiab thiab xa cov ntaub ntawv raw tshiab - ib qho txheej txheem qeeb, siv nyiaj ntau. Cov ntaub ntawv propionic acid qhia tau hais tias ntau cov organic acids uas tau tsim zoo, uas tau sau npe ntev tsuas yog cov tshuaj preservatives, pH adjusters lossis chelating agents, muaj peev xwm tsis tau siv. Qhov no tsim ib txoj hauv kev tsim cov kab mob me me uas pheej yig thiab ua raws li txoj cai rau cov hom lag luam me me hauv Suav teb uas tsis muaj peev txheej los thov kev pom zoo rau cov khoom siv raw tshiab.
Piv txwv li, AHAs tau raug nkag siab tias yog cov tshuaj exfoliants thiab pH modifiers xwb. Cov kws tshawb fawb tom qab ntawd tau lees paub tias lactic acid, ib qho organic metabolite luv luv uas tsim los ntawm epidermal lactobacilli, ua rau cov tshuaj moisturizing factor synthesis zoo dua thiab txhawb nqa daim tawv nqaij lub zog tiv thaiv acidic. L'Oréal thiab nws lub npe La Roche-Posay sib xyaw nws cov "AP+M Microbiome Remodelling Technology" nrog cov lactic acid tsawg thiab postbiotics los txhawb nqa daim tawv nqaij thaiv rau cov neeg mob uas muaj atopic eczema. Unilever-owned Gallinée tsim nws cov khoom siv microbiome skincare nyob ib puag ncig lactic acid thiab lactobacillus-derived postbiotics.
Qhov thib ob, qhov kev tshawb pom no qhia txog kev hloov pauv tseem ceeb hauv kev tsom mus rau microbiome R&D mus rau qhov uas ntau tus neeg hu ua "metabolite era".
Kev tshawb nrhiav tseem ceeb tshaj qhov kev txheeb xyuas cov kab mob twg nyob hauv daim tawv nqaij, mus rau kev tshawb nrhiav cov metabolites uas cov kab mob no tsim tawm, thiab cov metabolites no tswj hwm kev tiv thaiv keratinocyte thiab kev mob o. Kev tshawb fawb tab tom ua kom muaj ntau ntxiv thiab tsom mus rau lub hom phiaj.
Ntau daim ntawv tshawb fawb los ntawm Dr. Althea (Euromed, Freda Biotech) pab pawg tau raug xaiv los nthuav qhia ntawm IFSCC Congresses ua raws li qhov kev tshawb fawb no, kos duab sebum-short-chain fatty acid feedback loops. Pawg Freda Biotech siv metabolomics rau cov qauv piv ntawm cov short-chain fatty acids thiab cov free fatty acids uas tsim los ntawm epidermal microbes metabolising cutaneous sebum.
Shiseido tau tsim nws txoj kev npaj Skin Microbiome Focus , uas tsom mus rau kev tshawb fawb txog glycerol thiab cov organic metabolites luv luv uas tsim los ntawm Staphylococcus epidermidis . Nws lub chaw tshawb fawb tau lees paub tias cov organic metabolites uas tsim los ntawm cov kab mob ntawm daim tawv nqaij pab ua kom cov keratinocyte receptors ua haujlwm thiab ua kom cov protein sib txuas nruj xws li Claudin-1 nce ntxiv. Kev tshawb fawb no tau txhawb nqa kev hloov pauv ntawm Shiseido's d program range, uas tsim los txhawb kev tsim cov microbial metabolites zoo rau kev saib xyuas microbiome.
Qhov thib peb, qhov sib txawv no ua rau muaj kev pheej hmoo tshiab rau kev lag luam thiab kev ua raws li txoj cai.
Cov hom lag luam yuav tsum sib txuas lus kom meej rau cov neeg siv khoom thiab cov neeg tswj hwm tias cov khoom xyaw tib yam muab cov txiaj ntsig sib txawv nyob ntawm qhov concentration thiab pH ntawm cov mis: cov tshuaj propionic acid ntau ntau khaws cia cov khoom kom ruaj khov thiab ruaj khov, thaum cov concentration qis hauv lub cev txhawb nqa kev kho qhov thaiv, thiab cov haujlwm no tsis yog sib cais. Hauv Suav teb lub kaw lus sau ntawv, propionic acid lub luag haujlwm sau npe tseem khaws cia. Cov hom lag luam yuav tsum cais cov ntaub ntawv sau ntawv tawm ntawm cov lus tshaj tawm kev lag luam kom tsis txhob muaj cov lus thov tsis muaj pov thawj lossis ua kom dhau.
Cov hom lag luam zoo nkauj huv si feem ntau tau tawm tsam nrog kev ruaj khov thiab kev pheej hmoo ntawm kev puas tsuaj uas cuam tshuam nrog cov qauv tsis muaj tshuaj tiv thaiv. Tus qauv Esse thiab AFYREN siv 100% biobased fermented propionic acid. Hauv cov qauv no, cov khoom xyaw ua tau raws li COSMOS / ECOCERT cov qauv ntawv pov thawj ntuj thaum ua lub luag haujlwm ob: kev txuag me me ntawm kev thauj khoom txo qis nrog rau kev kho cov khoom zoo li postbiotic.
Nws yog qhov tsim nyog los kwv yees tias thaum kev tshawb fawb txog cov roj fatty acids luv luv nthuav dav, cov organic acids uas khaws cia ntau dua yuav raug rov ntsuam xyuas dua thiab rov siv dua rau cov txiaj ntsig tshiab ntawm daim tawv nqaij.
Leecosmetic: Siv cov ntaub ntawv raw los ntawm cov tuam txhab nto moo thoob ntiaj teb
Hu rau: https://leecosmetic.com/contactus/
Siv Daim Ntawv Sau
- AFYREN Cov Xov Xwm Tshaj Tawm: Kev tso tawm thoob ntiaj teb ntawm cov khoom siv pleev ib ce raws li AFYREN's 100% natural propionic acid
- Kev Nkag Siab Txog Kev Saib Xyuas Tus Kheej: Esse tso tawm Afyren petrochemical-free propionic acid hauv microbiome daim tawv nqaij cream
- Qiu Z, thiab lwm tus. Ib qho axis sebum–microbial metabolite–IL-33 uas tsis ua haujlwm zoo ua rau daim tawv nqaij o hauv atopic dermatitis. Phau Ntawv Xov Xwm Txog Kev Kho Mob Sim, 2022, 219(10): e20212397
- CosIng EU cov ntaub ntawv nkag mus rau Propionic acid
- Xov Xwm Txog Cov Pa roj Carbon Uas Rov Ua Dua Tshiab: Kev tso tawm thoob ntiaj teb ntawm cov khoom siv pleev ib ce raws li AFYREN's 100% natural propionic acid
- UniVOOK nplooj ntawv khoom lag luam rau biobased propionic acid
- IFSCC - Lub Koom Haum Thoob Ntiaj Teb ntawm Cov Koom Haum ntawm Cov Kws Tshuaj Pleev Xim, cov chaw khaws ntaub ntawv tshawb fawb (cov ntawv luv luv ntawm cov roj fatty acid & cov ntawv microbiome ntawm daim tawv nqaij)
- Kev piav qhia txog Shiseido Skin Microbiome Research Program
- Kev Tshawb Fawb Txog Kab Mob Microbiome ntawm La Roche-Posay & Kev Tshawb Fawb Tom Qab Muaj Kab Mob
- NMPA Cov Ntawv Teev Cov Khoom Siv Pleev Xim Siv Lawm (2021 Tsab official portal)
