Ukuze kulungiswe isithiyo sesikhumba, abakhiqizi babegxile ekugcwaliseni uwoyela namanzi, njengokufana “nokupenda udonga.” Kodwa-ke, izinkampani ezinkulu zezinto zokusetshenziswa embonini manje seziqhuba isu elisha: ukulungiswa kwangempela kuqala ngokuthuthukisa isithiyo sokuzivikela sesikhumba.
Ngo-2026, i-dermatology yomhlaba wonke iyaqhubeka nokuhlolisisa izinga lemishini, iguqula izindlela zendabuko ezazinganikeza ukulungiswa kwezinga lobuso kuphela. Namuhla, umncintiswano wobuchwepheshe wokulungisa izithiyo zesikhumba usuphenduke iphrojekthi yobunjiniyela besistimu eyinkimbinkimbi—engancikile nje ekuxhumaniseni izithako eziningi kodwa futhi eyakha “umsele” wobuchwepheshe wabakhiqizi.
Muva nje, inkampani enkulu yezinto zokusetshenziswa i-dsm-firmenich yethule ngokusemthethweni i-Glycare™ SK , ipulatifomu entsha sha esekelwe ku- Human Milk Oligosaccharides (HMOs) . Izithako eziyinhloko ezikhishwe ngasikhathi sinye, i-Glycare™ SK Renew kanye ne -Glycare™ SK Comfort , zicindezela ngqo ukulungiswa kwezithiyo zesikhumba zibe yisigaba esisha sokuzivikela komzimba kanye nokulawulwa kwe-microbiome.
Ingxenye 01: Kusukela Ekulungisweni Komphezulu Kuya Ekulawulweni Okujulile Kwesithiyo Sesikhumba
Isikhathi eside, ukuqonda okufushane kwemboni yokunakekelwa kwesikhumba yomhlaba wonke ngesithiyo sesikhumba kwakusekelwe kakhulu kumodeli ethi “Brick and Mortar” [1]. Kodwa-ke, empeleni, izici zesikhumba ziyinkimbinkimbi kakhulu kunalokho okushiwo yile modeli.
Ngokuphathelene nendlela yendabuko: Abakhiqizi abaningi balungisa isithiyo sesikhumba ngokugcwalisa kabusha ama-ceramides, ama-fatty acid, kanye ne-cholesterol. Nakuba le ndlela yokugcwalisa kabusha eqondiwe isebenza kahle, empeleni yelapha izimpawu hhayi imbangela eyinhloko—izinkinga eziyisisekelo azikaxazululwa.
Inkinga ejulile evezwe lapha yile: Ucwaningo lwezokwelapha lwanamuhla luthole ukuthi ngenxa yokuzwela kwesikhumba okuphindaphindiwe kanye nomonakalo wezithiyo, imbangela eyinhloko isekusebenzeni ngokweqile kwezimpendulo zomzimba wesikhumba kanye nokungalingani kwe-microbiome [2]. Lezi zinkinga ezijulile azikwazi ukuxazululwa ngezindlela zendabuko zokunakekelwa kwesikhumba.
Ngokusho kocwaningo olukuyi- Journal of Investigative Dermatology , lapho i-epidermis yonakele, ama-keratinocyte akhipha izinto ezibonisa izimpawu ezifana ne -IL-1α kanye ne-TSLP (Thymic Stromal Lymphopoietin) [3]. Ngaphezu kwalokho, lapho isithiyo sesikhumba sonakele futhi amazinga e-pH ekhuphuka, i-Staphylococcus aureus yanda ngokweqile. Ucwaningo lufakazela ukuthi ingakhipha ngqo ama-protease ukuze yonakalise i-filaggrin yesikhumba. Ngokuphathelene nalokhu, i-Nature ishicilele ukuthi ukuhlukahluka kwamagciwane ezigulini ezine-atopic dermatitis (ukuzwela okukhulu) kuphansi kakhulu, okuvame ukuhambisana nokuqongelela kwe- Staphylococcus aureus [4].
Ucwaningo oluvela kumajenali anegunya njenge- Journal of Investigative Dermatology lubonisa ukuthi kukhona ukusayinwa phakathi kwezitshalo zangaphakathi zesikhumba kanye nama-keratinocyte. Uma lokhu kulinganisela kuphazamiseka, isikhumba sihlala sisesimweni sokuzwela kakhulu nokuvuvukala, noma ngabe amafutha agcwaliswa kabusha kusetshenziswa izindlela zendabuko.
Umqondo oyisisekelo we -Glycare™ SK uhlukile ezindleleni zendabuko. Ngokulingisa izindlela zokuvikela zezigaba zokuphila kwasekuqaleni, isebenzisa i-molecule yesignali esebenzayo kakhulu— i-HMO —ukulungisa kabusha ukubekezelelana kwesikhumba nokuzivikela, okuvumela isikhumba ukuthi sifinyelele kancane kancane ekuzilawuleni.
Ingxenye 02: I-HMO—“Igugu Elihlanganisa Izindawo Ezihlukahlukene” Lesayensi Yesikhumba
Ama-Oligosaccharide obisi lomuntu (ama-HMO) ayingxenye yesithathu ngobukhulu eqinile ebisini lebele.
1. Indlela Yesayensi [5]
Izincwadi zesayensi zibonisa ukuthi ama-HMO awayona ingxenye eyodwa kodwa aqukethe ama-molecule e-carbohydrate ayinkimbinkimbi angaphezu kuka-200. Anomsebenzi oyingqayizivele "we-decoy receptor" :
Umphumela wokulwa nokunamathela: Isakhiwo sama-molecule sama-HMO sifana kakhulu nama-receptor ebusweni bamaseli esikhumba. Ama-bacteria ayingozi abopha ngephutha kuma-molecule e-HMO esikhundleni sama-receptor angempela. Ngenxa yalokho, ama-bacteria ayingozi ahlala elenga ebusweni besikhumba, angakwazi ukunamathela kumaseli, futhi ekugcineni ahlanzwa ngokusebenzisa i-metabolism evamile yesikhumba.
Ukulawulwa Kwamasosha Omzimba: Njengama-prebiotic, ama-HMO akhuthaza ngokukhethekile ukukhula kwamagciwane anenzuzo (njenge- Bifidobacterium kanye nezinhlobo ezihambisanayo) futhi abophe ngqo kuma-receptors eseli lomzimba ukuze avimbele ukukhishwa kwezinto ezibangela ukuvuvukala [6].
2. Ukubiliswa Okunembile: Kusukela Elabhorethri Kuya Ekuthuthukisweni Kwezimboni
I-dsm-firmenich isebenzisa i-Precision Fermentation ukuze kufezwe ukukhiqizwa okukhulu kwezentengiselwano kwama-molecule amabili abalulekile e-HMO: i-2'-Fucosyllactose (2'-FL) kanye ne-Lacto-N-neotetraose (LNnT).
Okuphawulekayo ukuthi ukuhambisana kwayo kuyamangalisa. Nakuba ibizwa ngokuthi ama-Human Milk Oligosaccharides, ayiveli kubantu , okwenza ibe nesimilo esihle futhi ihlanzekile kakhulu [7]. Isebenzisa imikhiqizo ye-whey njengezinto ezisetshenziswayo futhi ikhiqizwa eYurophu kusetshenziswa amandla avuselelekayo.
1) Ukubilisa Ngokunembile
Isinyathelo 1: “Ukuhlela” kwezakhi zofuzo: Ososayensi baqala ngokutadisha isakhiwo sama-molecule sama-HMO obisini lwebele. Bese kuthi izingcezu zezakhi zofuzo ezikwazi ukuhlanganisa lawa ma-molecule kashukela zifakwe kuma-microorganisms aphephile.
Isinyathelo 2: “Ukuzalanisa” Okuphumelelayo: Uma sezishintshiwe, lezi zinambuzane zinekhono elikhethekile lokukhiqiza ama-HMO ngobuningi. Ziba “imishini enembile” ngokukhethekile yokwenza i-2′-FL noma i-LNnT.
Isinyathelo 3: Ukubilisa nge-bio: Lawa ma-microorganism aguqulwe ngokwenziwa afakwa emathangini amakhulu okubilisa ngensimbi engagqwali. I-dsm-firmenich isebenzisa ngobuhlakani i-lactose evela ku-whey “njengokudla.”
2) Ukucubungula Okuphansi
Ngesikhathi sokukhiqiza, abakhiqizi balawula ngokuqinile izinga lokushisa, i-pH, kanye nomoya-mpilo, okuvumela ama-microorganism ukuthi adle i-lactose futhi ahlanganise ama-molecule e-HMO ahlanzekile. Ngemva kokubilisa, ithangi liqukethe ingxube yama-microorganism kanye nama-metabolites ayinkimbinkimbi. Ukuze kufezwe ubumsulwa obuphezulu bezinga lobuhle, kudingeka ukukhipha okuqinile kakhulu:
Ukuhlukaniswa Kwamaseli: Amaseli e-microbial asuswa ngezindlela ezifana nokuhlunga okungaphezulu.
Ukususa umbala kanye nokususa umbala: Ama-pigment namaminerali akhiqizwa ngesikhathi sokubilisa ayasuswa.
Ukuhlanzwa Okuhle: Umkhiqizo wokugcina awunazo izinto ezithathwe ngabantu futhi awunayo i-DNA evela kuma-microorganisms aguqulwe izakhi zofuzo.
Ukwakheka kwekristalu nokomisa: Umphumela uba impuphu noma uketshezi olumhlophe, oluhlanzekile kakhulu (ngaphezu kuka-95%-98%) lwe-HMO.
Ingxenye 03: Ubufakazi Bezokwelapha—Ukuphepha Okusekelwe Kudatha
Ipulatifomu ye-Glycare™ SK inikeza ukwesekwa kwedatha okuqondiswe ngqo kwezidingo zesikhumba ezahlukene:
I-Glycare™ SK Renew: Ukulungiswa Okujulile Nokulwa Nokuguga
Esikhumbeni esonakele kakhulu, i-Renew ikhombisa amakhono okwakha kabusha isikhumba. Idatha ye-in vitro ikhombisa ukuthi ingakhuphula kakhulu amazinga e-collagen yohlobo I ngamaphesenti afinyelela ku-67 , okungagcini nje ngokulungisa isithiyo kodwa futhi okwandisa i-dermal matrix.
Ukusebenza Kwezokwelapha (amasonto ayi-8):
I-TEWL (Ukulahlekelwa Kwamanzi Kwe-Transepidermal) kwehle ngo- 19%.
Ukubomvu okubonakalayo kwehle ngo- 38% , okuthuthukisa kakhulu i-hyperpigmentation kanye ne-telangiectasia ebangelwa ukuvuvukala okungapheli [8].
Induduzo ye-Glycare™ SK: Ukuzivikela Kwansuku Zonke Nokududuza Okuhlala Isikhathi Eside
Igxile ezinkingeni "zesikhumba esibuthakathaka" phakathi kwabathengi basemadolobheni abaphakathi nendawo, iComfort igxile ekugcineni i-homeostasis.
Ukumanzisa Okusheshayo: Ukuqukethwe kwamanzi esikhumbeni kukhuphuke ngo- 13% phakathi namasonto ama-4.
Ukuhlanganiswa Kwezithiyo: Ukulahleka kwamanzi kwehle ngo- 16% zingakapheli amasonto ayisishiyagalombili.
Ukuqeda ukuzwela: Ngokulawula i-microbiome, kunciphisa kakhulu imizwa yokuhlaba ebangelwa yizinto ezingaphandle.
| I-Metric | Ukuvuselelwa kwe-Glycare™ SK | Induduzo ye-Glycare™ SK |
| Izinzuzo Zesisindo | Ukwakhiwa kabusha okujulile, ukulwa nokuvuvukala, nokukhuthaza i-collagen | Ukuqina kwamanzi isikhathi eside, i-microbiome homeostasis |
| Ukuncipha kwe-TEWL | 19% (amasonto ayi-8) | 16% (amasonto ayi-8) |
| Ukuthuthukiswa kobomvu | 38% (amasonto ayi-8) | Ukuthuthukiswa okuzinzile |
| Idatha Ekhethekile | Uhlobo I lwe-Collagen +67% | Okuqukethwe kwamanzi +13% (amasonto ama-4) |
Ingxenye 04: Ukuhlaziywa Kwemikhuba Yemboni—Ingabe I-Microbiome + Ukungavikeleki Kwemvelo Kuyisiqalo Esilandelayo Esiphezulu?
Njengamanje, ama-HMO asevele “ayisithako esivelele” sasekhaya emafomuleni ezinsana asezingeni eliphezulu. Kodwa-ke, ohlelweni lokwakheka kwesikhumba, ama-HMO aseyinto entsha.
Ngenxa yenqubo eyinkimbinkimbi yokwenziwa kwama-HMO, engadingi nje kuphela ubumsulwa obukhulu kodwa futhi nokuzinza ngaphakathi kwezakhi, lokhu kunikeza abakhiqizi "umsele" wobuchwepheshe obuphezulu.
Ngokufigqiwe:
Ipulatifomu ye-Glycare™ SK evela ku-dsm-firmenich akuyona nje ukwethulwa kwesithako, kodwa ukulethwa kwesisombululo sokulungisa amasosha omzimba se-biomimetic . Ukuvela kwayo kubonisa ukuthi ukunakekelwa kwesikhumba kuya “enkathini ehlakaniphile ye-Bio.” Kubanikazi bomkhiqizo abafuna ukuncintisana okuhlukile, ama-HMO ngokungangabazeki ayingxenye elandelayo yesisindo esinzima enokusekelwa okuqinile kwesayensi kanye nombono wabathengi, kulandela i-biology yokwenziwa kanye ne-collagen ephindaphindayo.
I-Leecosmetic: Ukusebenzisa izinto ezingavuthiwe ezivela ezinkampanini ezidumile emhlabeni jikelele
Xhumana: https://leecosmetic.com/contactus/
Imithombo Yezikhombo Ezigunyaziwe:
[1] Elias, PM (1983). Umsebenzi wokuvimbela i-Epidermal: ukuhlukahluka kokuxhumana kwabantu kanye nokwezinhlobo ezahlukene. Ijenali ye-Investigative Dermatology.
[2] Belkaid, Y., & Harrison, OJ (2017). Ukungavikeleki Kwasekhaya kanye ne-Microbiota. Ukungavikeleki Kwangaphakathi.
[3] Ziegler, SF (2012). I-Thymic stromal lymphopoietin (TSLP): umlawuli oyinhloko wezifo zokungezwani komzimba. Ijenali Yesikhumba Esiphenyayo.
[4] Byrd, AL, et al. (2018). I-microbiome yesikhumba somuntu. Ukubuyekezwa Kwemvelo I-Microbiology.
[5] Bode, L. (2012). Ama-oligosaccharide obisi lomuntu: Wonke umntwana udinga umama oshukela. I-Glycobiology.
[6] Triantis, V., et al. (2018). Imiphumela Yesimiso Sokuzivikela Emzimbeni Yama-Oligosaccharides Obisi Lomuntu. Imingcele Kwezokwelapha Zezingane.
[7] dsm-firmenich Technical White Paper (2025). Ukubiliswa Okunembile kanye Nokucubungula Okuphansi Kwama-HMO Okusetshenziswa Ngaphakathi.
[8] Umbiko Wocwaningo Lwezokwelapha lwe-Glycare™ SK (2025). Ukusebenza kahle kwe-2′-FL kanye ne-LNnT ekulungisweni Kwezithiyo Zesikhumba kanye Nokunciphisa Ubomvu.
