Pofuna kukonza chotchinga cha khungu, opanga kale ankaganizira kwambiri za kudzaza mafuta ndi madzi, monga "kupaka khoma." Komabe, makampani akuluakulu opanga zinthu zopangira zinthu tsopano akuyendetsa njira yatsopano: kukonza kwenikweni kumayamba ndi kukonza khungu. chotchinga cha chitetezo chamthupi.
Mu 2026, akatswiri a khungu padziko lonse lapansi akupitilizabe kufufuza za makina, kusintha njira zachikhalidwe zomwe zingapereke kokha kukonzanso pamwamba. Masiku ano, mpikisano waukadaulo wokonzanso zotchinga pakhungu wakhala ntchito yovuta kwambiri yokonza zinthu—yomwe imadalira osati kokha kugwirizana kwa zosakaniza zingapo komanso kupanga "dzenje" laukadaulo kwa opanga.
Posachedwapa, kampani yayikulu yopanga zinthu zopangira dsm-firmenich anakhazikitsidwa mwakhama Glycare™ SK, nsanja yatsopano yozikidwa pa Ma Oligosaccharide a Mkaka wa Anthu (HMOs)Zosakaniza zazikulu zomwe zimatulutsidwa nthawi imodzi, Glycare™ SK Yatsopano ndi Chitonthozo cha Glycare™ SK, kukakamiza mwachindunji kukonzanso zotchinga pakhungu kupita ku gawo latsopano la chitetezo chamthupi komanso malamulo a tizilombo toyambitsa matenda.
Gawo 01: Kuyambira Kukonza Pamwamba mpaka Kulamulira Kwambiri Chotchinga cha Khungu
Kwa nthawi yayitali, kumvetsetsa mwachidule kwa makampani osamalira khungu padziko lonse lapansi pankhani yokhudza chotchinga pakhungu kunali kozikidwa makamaka pa Chitsanzo cha "Brick and Mortar" [1]. Komabe, zoona zake n'zakuti, makhalidwe a khungu ndi ovuta kwambiri kuposa momwe chitsanzochi chikusonyezera.
Ponena za njira yachikhalidwe: Opanga ambiri amakonza zotchinga khungu mwa kudzazanso ma ceramides, mafuta acids, ndi cholesterol. Ngakhale kuti njira yowonjezerera iyi ndi yothandiza, kwenikweni imachiza zizindikiro osati chomwe chimayambitsa - mavuto omwe amayambitsa sanathetsedwebe.
Vuto lalikulu lomwe lafotokozedwa apa ndi ili: Kafukufuku wamakono wa zamankhwala wapeza kuti chifukwa cha khungu losachedwa kuwonongeka komanso kuwonongeka kwa zotchinga, chomwe chimayambitsa vutoli ndi kugwira ntchito mopitirira muyeso kwa chitetezo cha mthupi pakhungu ndi kusalinganika kwa microbiome [2]. Mavuto ozama awa sangathetsedwe kudzera m'njira zachikhalidwe zosamalira khungu.
Malinga ndi kafukufuku wa mu Journal of Investigative Dermatology, khungu likawonongeka, ma keratinocyte amatulutsa zinthu zodziwitsa monga IL-1α ndi TSLP (Thymic Stromal Lymphopoietin) [3]. Komanso, pamene chotchinga cha khungu chawonongeka ndipo pH ikukwera, Staphylococcus aureus imachulukana kwambiri. Kafukufuku wasonyeza kuti imatha kutulutsa ma protease mwachindunji kuti iwononge khungu la filaggrin. Ponena za izi, Nature yafalitsa kuti kusiyanasiyana kwa tizilombo toyambitsa matenda mwa odwala omwe ali ndi atopic dermatitis (kukhudzidwa kwambiri) ndi kochepa kwambiri, nthawi zambiri kumayenderana ndi kufalikira kwa matenda. Staphylococcus aureus [4]
Kafukufuku wochokera m'magazini odalirika monga Journal of Investigative Dermatology Zimasonyeza kuti pali zizindikiro pakati pa zomera za pakhungu ndi ma keratinocyte. Pamene kulinganiza kumeneku kwasokonekera, khungu limakhalabe mu mkhalidwe wovuta kwambiri komanso wotupa, ngakhale mafuta atawonjezeredwa pogwiritsa ntchito njira zachikhalidwe.
Mfundo yaikulu ya Glycare™ SK Zimasiyana ndi njira zachikhalidwe. Mwa kutsanzira njira zotetezera za magawo oyambirira a moyo, zimagwiritsa ntchito molekyulu yolumikizirana yomwe imakhala ndi mphamvu zambiri—HMO—kukonzanso mphamvu ya chitetezo cha mthupi cha khungu, zomwe zimathandiza kuti khungu lizitha kudzilamulira pang'onopang'ono.
Gawo 02: HMO—“Mwala Wosiyanasiyana” wa Sayansi ya Khungu
Ma Oligosaccharides a Mkaka wa Munthu (HMOs) ndi gawo lachitatu lalikulu kwambiri mu mkaka wa m'mawere.
1. Njira ya Sayansi [5]
Mabuku asayansi amasonyeza kuti ma HMO si gawo limodzi koma amapangidwa ndi mamolekyulu opitilira 200 a chakudya chopatsa mphamvu. Ali ndi kapangidwe kake kapadera "cholandirira cha decoy" Ntchito:
Zotsatira zotsutsana ndi kuuma: Kapangidwe ka mamolekyu a ma HMO ndi kofanana kwambiri ndi ma receptor pamwamba pa maselo a khungu. Mabakiteriya oopsa amalumikizana molakwika ndi mamolekyu a HMO m'malo mwa ma receptor enieni. Zotsatira zake, mabakiteriya owopsawo amakhalabe pamwamba pa khungu, osatha kukhazikika pa maselo, ndipo pamapeto pake amatsukidwa ndi kagayidwe kabwino ka khungu.
Kuwongolera kwa Immune Regulation: Monga prebiotics, ma HMO amalimbikitsa kukula kwa mabakiteriya opindulitsa (monga Bifidobacterium ndi mitundu ina yofanana) ndipo imalumikizana mwachindunji ndi ma immune cell receptors kuti ilepheretse kutulutsidwa kwa zinthu zomwe zimayambitsa kutupa [6].
2. Kuphika Moyenera: Kuchokera ku Laboratory mpaka ku Industrial Development
dsm-firmenich imagwiritsa ntchito Kuphika Moyenera kuti akwaniritse kupanga mamolekyu awiri ofunikira a HMO m'malonda: 2'-Fucosyllactose (2'-FL) ndi Lacto-N-neotetraose (LNnT).
Chochititsa chidwi n'chakuti, kutsatira kwake n'kwabwino kwambiri. Ngakhale kuti amatchedwa Human Milk Oligosaccharides, ndi osati kuchokera kwa anthu, kuwapangitsa kukhala a makhalidwe abwino komanso oyera kwambiri [7]. Amagwiritsa ntchito zinthu zopangidwa ndi whey ngati zinthu zoyambira ndipo amapangidwa ku Europe pogwiritsa ntchito mphamvu zongowonjezwdwanso.
1) Kuphika Moyenera
Gawo 1: "Kupanga Mapulogalamu" a Gene: Asayansi amayamba kuphunzira kapangidwe ka mamolekyu a ma HMO mu mkaka wa m'mawere. Kenako, zidutswa za majini zomwe zimatha kupanga mamolekyu a shuga amenewa zimayikidwa m'mabakiteriya otetezeka.
Gawo 2: "Kubereka" Moyenera: Tizilombo toyambitsa matenda timeneti tikasinthidwa, timakhala ndi luso lapadera lopanga ma HMO ambiri. Timakhala "makina olondola" makamaka opangira 2′-FL kapena LNnT.
Gawo 3: Kuphika kwa biofermentation: Tizilombo toyambitsa matenda tomwe tasinthidwa mwaluso timayikidwa m'matanki akuluakulu achitsulo chosapanga dzimbiri. dsm-firmenich imagwiritsa ntchito lactose yochokera ku whey ngati "chakudya."
2) Kukonza Pansi pa Mtsinje
Pakupanga, opanga amawongolera kutentha, pH, ndi mpweya, zomwe zimathandiza kuti tizilombo toyambitsa matenda tizitha kudya lactose ndikupanga mamolekyu oyera a HMO. Pambuyo pophika, thankiyo imakhala ndi mitundu yosiyanasiyana ya tizilombo toyambitsa matenda ndi zinthu zovuta kupanga. Kuti tipeze kuyera kwambiri kwa cosmetic grade, kuchotsedwa mwamphamvu kwambiri kumafunika:
Kulekanitsa Maselo: Maselo a tizilombo toyambitsa matenda amachotsedwa pogwiritsa ntchito njira monga ultrafiltration.
Kusintha Mtundu ndi Kusintha Mtundu: Utoto ndi mchere zomwe zimapangidwa panthawi yophika zimachotsedwa.
Kuyeretsa Kwabwino: Chogulitsa chomaliza chilibe zinthu zochokera kwa anthu komanso DNA yochokera ku tizilombo tomwe tasinthidwa majini.
Kukonza ndi Kuumitsa: Zotsatira zake zimakhala zoyera, zoyera kwambiri (zoposa 95%-98%) za ufa wa HMO kapena madzi.
Gawo 03: Umboni Wachipatala—Chitetezo Chochokera ku Deta
Pulatifomu ya Glycare™ SK imapereka chithandizo cha deta yowunikira zosowa zosiyanasiyana za khungu:
Glycare™ SK Renew: Kukonza Kwambiri ndi Kuletsa Kukalamba
Pa khungu lowonongeka kwambiri, Renew ikuwonetsa mphamvu zokonzanso khungu. Deta ya in vitro ikuwonetsa kuti ikhoza kuwonjezereka kwambiri Ma collagen amtundu woyamba amafika pa 67%, zomwe sizimangokonza chotchingacho komanso zimakulitsa khungu.
Kuchita bwino kwachipatala (masabata 8):
TEWL (Kutayika kwa Madzi a Transepidermal) kunachepa ndi 19%.
Ziwoneka zofiira adachepa ndi 38%, zomwe zimathandizira kwambiri kusintha kwa mtundu wa pigmentation ndi telangiectasia chifukwa cha kutupa kosatha [8].
Chitonthozo cha Glycare™ SK: Chitetezo cha Tsiku ndi Tsiku ndi Chitonthozo Chokhalitsa
Polimbana ndi mavuto a "khungu lofooka" pakati pa ogula apakati m'mizinda, Comfort imayang'ana kwambiri pakusunga homeostasis.
Instant Hydration: Madzi a pakhungu amawonjezeka ndi 13% pasanathe milungu 4.
Kuphatikiza Zopinga: Kutayika kwa madzi kunachepa ndi 16% pasanathe milungu 8.
Mpumulo wa Kuzindikira Kukhudzidwa: Mwa kulamulira microbiome, imachepetsa kwambiri kulira komwe kumachitika chifukwa cha zinthu zakunja.
| Miyeso | Glycare™ SK Yatsopano | Chitonthozo cha Glycare™ SK |
| Zabwino Zabwino | Kumanganso mwakuya, kuletsa kutupa, komanso kulimbikitsa collagen | Kuthamanga kwa madzi kwa nthawi yayitali, microbiome homeostasis |
| Kuchepa kwa TEWL | 19% (masabata 8) | 16% (masabata 8) |
| Kupititsa patsogolo Kufiira | 38% (masabata 8) | Kusintha kokhazikika |
| Deta Yapadera | Kolajeni ya Mtundu Woyamba + 67% | Kuchuluka kwa Madzi +13% (masabata 4) |
Gawo 04: Kusanthula Zochitika Zamakampani—Kodi Microbiome + Chitetezo Chamthupi Ndiwo Malo Otsatira Ofunika Kwambiri?
Pakadali pano, ma HMO ndi chinthu chodziwika bwino kwambiri m'mafakitale apamwamba a ana. Komabe, mu njira yosamalira khungu, ma HMO akadali chinthu chatsopano.
Chifukwa cha njira yovuta yopangira ma HMO, yomwe imafuna kuyera kwambiri komanso kukhazikika mkati mwa mapangidwe, izi zimapatsa opanga "mchenga" wapamwamba kwambiri.
Powombetsa mkota:
Pulatifomu ya Glycare™ SK yochokera ku dsm-firmenich si kungoyambitsa chosakaniza, komanso kupereka njira yothetsera vuto la chitetezo chamthupi (biomimetic immune repair solution)Kuwonekera kwake kukusonyeza kuti chisamaliro cha khungu chikupita patsogolo "Nthawi ya nzeru zamoyo." Kwa eni ake a kampani omwe akufuna mpikisano wosiyana, ma HMO mosakayikira ndi gawo lotsatira la heavyweight lomwe lili ndi chithandizo champhamvu cha sayansi komanso malingaliro a ogula, kutsata biology yopangidwa ndi collagen yopangidwanso.
Leecosmetic: Kugwiritsa ntchito zopangira zochokera kumakampani odziwika padziko lonse lapansi
Lumikizanani: https://leecosmetic.com/contactus/
Magwero Ovomerezeka Othandizira:
[1] Elias, PM (1983). Ntchito yotchinga khungu: kusiyana kwa anthu ndi mitundu yosiyanasiyana. Journal of Investigative Dermatology.
[2] Belkaid, Y., & Harrison, OJ (2017). Homeostatic Immunity ndi Microbiota. Chitetezo chokwanira.
[3] Ziegler, SF (2012). Thymic stromal lymphopoietin (TSLP): chowongolera chachikulu cha matenda a ziwengo. Journal of Investigative Dermatology.
[4] Byrd, AL, et al. (2018). Kachirombo kakang'ono ka khungu la munthu. Natural Reviews Microbiology.
[5] Bode, L. (2012). Ma oligosaccharide a mkaka wa munthu: Mwana aliyense amafunika shuga wokoma. Glycobiology.
[6] Triantis, V., et al. (2018). Zotsatira za Chitetezo cha Mthupi cha Ma Oligosaccharide a Mkaka wa Munthu. Malire mu Pediatrics.
[7] dsm-firmenich Technical White Paper (2025). Kuphika Moyenera ndi Kukonza Ma HMO Omwe Amagwiritsidwa Ntchito Pakhungu.
[8] Lipoti la Kafukufuku wa Zachipatala wa Glycare™ SK (2025). Kugwira ntchito bwino kwa 2′-FL ndi LNnT pakukonza zotchinga pakhungu ndi kuchepetsa kufiira.
