Na mmemme ngosi mbata mba ofesi nke China nke itoolu (CIIE), nke mechiri na Nọvemba 10, 2026, na National Exhibition and Convention Center (NECC) na Shanghai, China, nnukwu ụlọ ọrụ mma France bụ L'Oréal kpughere ihe kachasị ọhụrụ na nyocha ya nke dabere na glycan nke na-egbochi ịka nká. Site n'iji uru mgbochi mgbakasị ahụ, ike, na nri miri emi lekọta akpụkpọ ahụ toro eto, otu a malitere ụwa ọhụrụ ya. Afọ Ọlaedo zuru oke (金致驭龄) nchịkọta, nke gụnyere ude, ihe mkpuchi mmanụ ọhụrụ, na serum microbead nke a na-etinye mmanụ.
N'inyocha usoro ngwaahịa na njikọta nhazi nke a na-egosi na pavilion ngwaahịa ndị ahịa, SKU atọ ahụ na-emepụta usoro nnyefe jikọtara ọnụ:
Ihe mkpuchi mmanụ ọhụrụ a na-etinye n'ime ude ọlaedo zuru oke maka afọ: Usoro abụọ a bụ nke mbụ a ga-etinye Sodium Colanate a gbazere n'ime mmiri (INCI): Sodium Colanate nke a gbazere agbaze), ihe e ji enzyme hydrolyzed nke ụlọ ọrụ bayọlọji sịntetik nke China mepụtara Shenzhen Boyin Biotechnology (nke a na-akpọ PAM²L n'ụwa niile, isi ụlọ ọrụ ya dị na Shenzhen, Guangdong Province, China)N'ime usoro a, ihe mkpuchi mmanụ na-emepụta ihe mgbochi lipid-occlusive iji mee ka ọ banye n'ime ahụ, ebe ude ahụ na-arụzi ihe mgbochi na-adịgide adịgide.
Ọbara Microbead nke a na-etinye n'ime mmanụ: Ejiri nnukwu molekul dị arọ mepụta ya Sodium Colanate (INCI: Sodium Colanate)serum a na-eji microfluidics iji kpuchido mmanụ dị mkpa ka ọ bụrụ obere ntapụ mmiri. Site n'ịchịkwa nrụgide dị n'etiti mmanụ na mmiri site na obere ọwa mmiri, teknụzụ a na-emepụta kapsụl akpụkpọ ahụ na-enweghị surfactant nke na-echekwa ọrụ lipophilic ma na-agbawa mgbe etinyere ya iji nye mmiri mmiri n'akụkụ nnyefe transdermal na-arụ ọrụ.
N'akụkụ iwu, Oil-Infused Microbead Serum mezuru ọkwa ịchọ mma na National Medical Products Administration (NMPA) nke China na Septemba 2026, ebe a na-enyocha ngwa maka ihe mkpuchi ude na mmanụ ugbu a. Nke kachasị mkpa bụ na kpọmkwem ụbọchị mmalite Shanghai, L'Oréal kwupụtara n'ihu ọha itinye ego atụmatụ na PAM²L iji mepụta ihe ndị na-emepụta ihe na-arụ ọrụ na ọgbọ na-esote.
Nnyocha Ngwakọta Miri-Mmiri: Mgbanwe site na Pro-Xylane ruo na Hydrolyzed Sodium Colanate
Iji nyochaa uru sayensị nke ihe mejupụtara ọhụrụ a nke ọma, ọ bara uru iji ya tụnyere molekul L'Oréal nke na-egbochi ịka nká—Pro-Xylane— n'akụkụ anọ dị mkpa: profaịlụ kemịkalụ, nhazi molekul, usoro mmepụta, na ebumnuche bayoloji.
1. Profaịlụ Kemịkalụ na Ọdịiche Nhazi
Sodium Colanate (INCI: Sodium Colanate) na Sodium Colanate a na-eme ka ọ dị ọcha (INCI: Sodium Colanate nke a gbazere agbaze): Sodium Colanate bụ ihe mejupụtara anionic exopolysaccharide (EPS) a na-emepụta ya site na nje bacteria. Nkọwapụta ihe owuwu na-egosi na ọkpụkpụ azụ polysaccharide ya nwere otu monosaccharide—gụnyere glucose, fucose, galactose, na glucuronic acid—nke ejikọtara site na njikọ glycosidic. Nkewa ya na-emegharị ugboro ugboro nwere ihe fọdụrụ monosaccharide isii nke agbanwere na otu acetyl na pyruvyl. Sodium Colanate nke na-enweghị mmiri mmiri, nke dị oke molekul, na-agafe oke ibu molekul sara mbara (10-6,000 kDa kwa akwụkwọ ikike patent) ma e jiri ya mee ihe na mbụ dị ka ihe na-echebe akpụkpọ ahụ site na ihe mgbochi anụ ahụ. Site na eduzi enzyme hydrolysis, PAM²L na-eji hydrolases kpọmkwem iji kewaa njikọ glycosidic ma sie ike na polydispersity index (PDI), na-enye nkesa dị warara oligomeric sodium colanate (lekwasịrị anya na oke 1-10 kDa, yana akụkụ 1-3 kDa na 3-10 kDa na-egosi ọrụ bioactivity a ma ama na nyocha sel).
Profaịlụ Physicochemical nke Pro-Xylane (INCI: Hydroxypropyl Tetrahydropyrantriol):
Nọmba ndekọ CAS:
868156-46-1CC PubChem: Nchịkọta CC:
59696975Aha IUPAC:
(2S,3R,4S,5R)-2-((S)-2-Hydroxypropyl)tetrahydro-2H-pyran-3,4,5-triol (S-stereoisomer)Usoro na Ibu Molekụla:$\ederede{C}_8\ederede{H}_{16}\ederede{O}_5$, nke nwere oke molekul kpọmkwem nke
192.21 g/mol (Dá)Ọdịdị Nhazi: Obere molekul e ji aka mee, nke sitere na xylose, nke nwere mgbanaka nwere akụkụ isii nke nwere oxygen (azụ azụ C-glycoside).
Isi ihe dị mkpa gbasara teknụzụ: Ọbụna mgbe emesịa ekewapụchara enzymatic, Hydrolyzed Sodium Colanate ka bụ usoro nke polysaccharides oligomeric nwere ogo dị iche iche nke polymerization - nke pụtara na nha molekul ya n'ezie ka buru ibu karịa otu molekul192.21 DaPro-Xylane. Ntụaka ụlọ ọrụ na-ekwu maka "ibu molekul dị ala" ya bụ kpọmkwem ihe sitere na Sodium Colanate nke dị oke molekul (10–6,000 kDa), mana mbelata nha a na-eme ka njigide na mpụta nke stratum corneum ka mma nke ukwuu.
2. Usoro Ọrụ: Site na Matrix Extracellular (ECM) ruo na Mitochondrial Homeostasis
Ụzọ Pro-Xylane guzobere: Kemgbe L'Oréal webatara Pro-Xylane na 2006 (na-ebuga ya na Lancôme, Helena Rubinstein, SkinCeuticals, na L'Oréal Paris) ma kwalite ya ka ọ bụrụ Pro-Xylane PRO na 2022, nnyocha elekwasịla anya n'ịkpalite glycosaminoglycan (GAG) na njikọ proteoglycan, na-eme ka njikọ dermal-epidermal (DEJ) sie ike, na imegharị ya extracellular matriks (ECM).
Mgbasa nke ụzọ dị iche iche nke Sodium Colanate: Dịka data patent ebipụtara na ọmụmụ ihe gbasara bayọlọji ntọala si kwuo, ezinụlọ Sodium Colanate abụghị naanị na-akpali mmepụta collagen nke Ụdị nke Mbụ na Ụdị nke Atọ ma na-eme ka ihe mgbochi akpụkpọ ahụ sie ike, kamakwa ọ na-agbanwe ike sel nkịtị, nrụgide oxidative, na ụzọ ogologo ndụ—gụnyere NAMPT, SIRT1, AMPK, na mTORNchọpụta ụlọ nyocha na-egosikwa ike dị na iwepụ ụdị oxygen reactive intracellular (ROS), ibelata cytokines mkpali, na ịnọgide na-enwe homeostasis mitochondrial dynamic, na-ejikọta oghere dị n'etiti mmiri mmiri n'elu na nhazi microenvironment cell.
Data Nnyocha Nchekwa Ntanye Akwụkwọ ikike na Nyocha Nchekwa Nsí
Dịka ụkpụrụ iwu China si dị, PAM²L emechaala ọkwa ihe ịchọ mma ọhụrụ na NMPA (nke a ga-enyocha site na NMPA Cosmetic Ingredient Filing Platform): e debanyere aha Sodium Colanate n'ime Nọvemba 2023 (
国妆原备字20230056), sochiri ya Hydrolyzed Sodium Colanate na Mee 2025 (国妆原备字20250064Dịka iwu NMPA si dị, ihe abụọ a mere nyocha nchekwa zuru oke nke ihe ndị dị na ya - gụnyere nnukwu nsị ọnụ/akpụkpọ ahụ, mkpasu iwe akpụkpọ ahụ, na nnwale mmetụta akpụkpọ ahụ - a na-emepụta ha site na usoro ịgbaze na nhicha dị ala nke endotoxin dabara adaba maka akpụkpọ ahụ mebiri emebi ma tozuo etozu.N'ihe gbasara irè, PAM²L kpughere usoro nnwale ndị a na patent China
CN118593537A na patent PCT mba ụwa WO2025166972A1 (Onye otu mba Europe EP4623895A1):| Ụdị ihe mejupụtara ya | Ntụaka Patent | Ihe nlereanya na ọnọdụ ọmụmụ ihe | Nchịkọta arụmọrụ dị mkpa akọpụtara |
| Sodium Colanate nke obodo | Akwụkwọ ikike ndị ChinaCN118593537A (Ebipụtara 2024) | Nnwale Ahụike Mmadụ: Ndị mmadụ iri atọ na otu tinyere serum nwere 0.15% na-arụ ọrụ ugboro abụọ kwa ụbọchị (ụtụtụ/ehihie) ruo izu anọ | • Ogologo mgbagọ ụkwụ nke ugogbe belatara site na 38.03%, ọnụọgụ wrinkles belatara site na 35.68%
• Mmiri mmiri Stratum corneum mụbara site na 33.35%, mbelata mmiri transepidermal (TEWL) site na 19.84%
• Ọnụọgụ erythema akpụkpọ ahụ (hemoglobin) belatara site na 33.03% |
| Sodium Colanate a gbazere agbaze (Oligomeric) | Ikike Ndebanye Aha Mba NileWO2025166972A1 (Ebipụtara 2025) | Standard Na-Vitro Nnyocha Mkpanaka: Anwalere na 2 mg/mL (1–3 kDa nkebi) vs. nha nhata nke Pro-Xylane | • A kpaliri ya Ụdị I collagen mmepụta ihe dị ka ihe dị ka 4x ọnụego nke Pro-Xylane |
| Sodium Colanate a gbazere agbaze (Oligomeric) | Ikike Ndebanye Aha Mba NileWO2025166972A1 (Ebipụtara 2025) | Ịse foto site na UV Na-Vitro nnwale: Mmetụta mgbe ọkụ UV gasịrị na 2 mg/mL vs. nha nhata nke Pro-Xylane | • A kpaliri ya Ụdị I collagen njikọ na 2.3x ọnụego nke Pro-Xylane
• A kpaliri ya Ụdị nke III collagen njikọ na 2.8x ọnụego nke Pro-Xylane |
| Sodium Colanate a gbazere agbaze (Oligomeric) | Ikike Ndebanye Aha Mba NileWO2025166972A1 (Ebipụtara 2025) | Nnwale Ahụike Mmadụ: Ndị mmadụ iri isii na isii (afọ 30-60), na-enweghị usoro, na-etinye 0.5% serum na-arụ ọrụ maka ụbọchị 28 | • Elaghachi akpụkpọ ahụ (paịma R2) ka mma site na 40%
• Mmụba akpụkpọ ahụ site na 24%
• Ike njikọ nke eriri collagen mụbara site na 21.61%
• Mmiri mmiri Stratum corneum mụbara site na 63.84% |
(Rịba ama: Ọnụọgụ "4x Pro-Xylane" sitere na nyocha mkpụrụ ndụ in-vitro a na-achịkwa na mkpokọta pụrụ iche. Biko lee Nkọwa Sayensị dị n'okpuru gbasara oke ntụgharị dị n'etiti data in-vitro na ihe ịchọ mma emechara.)
Echiche nke onye nhazi: Nhazi na Ndakọrịta nke usoro
Maka ndị na-emepụta ihe na ndị na-azụ ahịa maara ihe mejupụtara ya, ha na-etinye Hydrolyzed Sodium Colanate n'ime ihe ndị ha na-eme kwa ụbọchị, usoro anionic oligomeric polysaccharide ya na-enye nnukwu nnabata na nkwekọ nhazi sara mbara:
Nchekwa Ike Dị Elu: N'ihi na Sodium Colanate na-emepụta ihe nkiri na-eku ume, nke na-eme ka ọrụ mgbochi sikwuo ike, na-etinye ya n'okpuru retinoids (retinol/retina) ma ọ bụ asịd na-ewepụ akpụkpọ ahụ (AHA/BHA) n'ihe omume mgbede nwere ike inye aka belata mkpasu iwe ma gbochie TEWL. Usoro nhazi akwadoro: Ihe nhicha → Mmiri Sodium Colanate Serum (ihe nchekwa mmiri) → Ọgwụgwọ Retinoid → Mmiri Moisturizer na-ekpuchi anya.
Njikọ ya na Peptides: Ma polysaccharides oligomeric na peptides signalar/carrier bụ ihe ndị na-agbaze mmiri, nke dabara na akpụkpọ ahụ, nke nwere obere ihe egwu nke enweghị ike ijikọ pH ma ọ bụ mmiri ozuzo nke chajị kpatara, na-eme ka ha bụrụ ezigbo njikọta ehihie maka nlekọta dị nro, nke a na-elekwasị anya n'ọtụtụ ebe.
Ọdịdị Ụwa Nile: Usoro Ngwakọta Bayọlọji Sịntetik nke China na Ịma Mma
Nnyocha agụmakwụkwọ banyere ịgbakọ mmiri nke colanic acid na nje bacteria enwetawo mmetụta zuru ụwa ọnụ n'ime afọ iri gara aga.
Mahadum Korea (Seoul, South Korea) tinyere akwụkwọ ikike ikike na 2019 (enyera na 2021) site na iji mgbanwe Escherichia coli ihe ndị na-akpata mmepụta colanic acid, Mahadum Jiangnan (Wuxi, Jiangsu Province, China) tinyere akwụkwọ ikike ikike na 2021 maka ihe ndị na-emepụta ihe dị elu. E. coli gbaa ụka.
Na 2022, ndị nchọpụta na-ebipụta akwụkwọ akụkọ nyocha nke ndị ọgbọ nyochara. Ormụ nje (Mpịakọta nke 10, Mbipụta nke 5) gosiri na injinịa metabolic combinatorial yana enzyme catalysis nwere ike ịkwanye titers colanic acid dị obere-molekul ruo
24.99 g/L n'ime bioreactor 3L.Ịsụgharị titers nke ụlọ nyocha ka ọ bụrụ ihe ịchọ mma nke ọkwa azụmaahịa nke na-emezu nkọwa siri ike nke ụlọ ọrụ ịma mma zuru ụwa ọnụ bụ ebe Usoro ọkọnọ ihe gbasara bayoloji sịntetik nke China ewepụtala uru pụrụ iche nke asọmpi. Nyocha ụlọ ọrụ McKinsey na Euromonitor na-egosi mgbanwe nhazi gaa na bio-fermentation na kemistri akwụkwọ ndụ akwụkwọ ndụ karịa mmepụta petrochemical ọdịnala na ihe ndị sitere na anụmanụ.
Na-eso ụzọ nke Bloomage Biotech (isi ụlọ ọrụ ya dị na Jinan, Shandong Province, China)—nke guzobere ọchịchị zuru ụwa ọnụ na hyaluronic acid site na molekul weight fractionation na chemical derivatization—dabere na Shenzhen PAM²L (na-ere ahịa ihe eji emepụta ihe ya n'okpuru akara akụrụngwa ya Kọlamini ika) ejirila ụlọ ọrụ mmepụta ihe dị elu, nke nwere obere endotoxin na hydrolysis nke enzyme ziri ezi iji kewaa n'ime usoro inye ihe ịchọ mma mba ụwa nke Tier-1.
Oke ego L'Oréal nwere na PAM²L na mbugharị ngwa ngwa nke Hydrolyzed Sodium Colanate n'ahịa abụghị naanị na ọ na-agbasa ikpo okwu mgbochi ịka nká nke otu French site na ihe ndị sitere na monosaccharide sịntetik gaa na polysaccharides dị mgbagwoju anya nke microbial bioactive, kamakwa ọ na-eguzobe usoro azụmaahịa a na-emegharị emegharị maka ihe ndị mejupụtara bayoloji sịntetik nke China na-abanye n'ahịa ịma mma ụwa.
Leecosmetic: Iji akụrụngwa sitere na ụlọ ọrụ ama ama na mba ụwa
Leecosmetic bụ a na-eduga ihe ịchọ mma emeputa. Ọ na-enye ngwaahịa ịchọ mma dị elu n'ọnụ ahịa asọmpi yana yana ọnụ ọgụgụ dị ala kacha nta.
Anyị na-enye ọtụtụ ọrụ, dị ka nkeonwe labelụ ịchọ mma n'ichepụta, OEM / ODM nrụpụta, ma na-enye ihe ngwọta zuru oke nke ngwaahịa maka obere na ọkara - nha ịchọ mma ụdị.
Dị ka onye na-emepụta ihe ịchọ mma nkeonwe na-eto ngwa ngwa, Leecosmetic na-eji akụrụngwa sitere na ụlọ ọrụ ama ama na mba ụwa n'ụzọ dị mma na nke ọma.
Kpọtụrụ: https://leecosmetic.com/contactus/
Ntuziaka & Isi mmalite data
1. Akwụkwọ ikike ndị China maka Sodium Colanate nke Native Anti-Aging Efficiency (
CN118593537A) — Nchịkwa Ihe Onwunwe Uche Mba China (CNIPA) / Akwụkwọ ikike Google: Ojiji nke ihe mejupụtara nwere colanate.2. PCT mba ụwa na ikike mba Europe maka Hydrolyzed Sodium Colanate (
WO2025166972A1 / EP4623895A1) — Ụlọ Ọrụ Patent nke Yuropu (EPO) / Akwụkwọ ikike Google: Ihe mejupụtara ya gụnyere nnu na ojiji nke colanic acid hydrolyzed.3. Patent Usoro Nchacha Ụlọ Ọrụ (
CN114957509B) — Shenzhen Boyin Biotechnology Co., Ltd. / Akwụkwọ ikike Google: Ụzọ kachasị mma iji kpochapụ colanic acid.4. Ọmụmụ Nyocha nke Ndị Ọgbọ Banyere Injinịa Metabolic & Mmepụta Enzymatic nke Colanic Acid (2022) — Li, S., na ndị ọzọ (2022). Njikọta Injinia Metabolic na Enzymatic Catalysis Na-eme Ka Mmepụta Colanic Acid Dị Mma. Ormụ nje, 10 (5), 877. DOI:
10.3390/microorganisms10050877.5. Ọmụmụ ihe ntọala gbasara Colanic Acid, Mitochondrial Homeostasis na Ogologo Oge (Cell, 2017) — Han, B., na ndị ọzọ (2017). Mkpụrụ ndụ ihe nketa nke microbial na-akwado Ogologo Oge. Cell, 169(7), 1249–1262. PMID:
28622510.6.Akụkọ Sayensị AAAS gbasara Ịgba Colanic Acid Ogologo Oge - Mahadum Ọgwụ Baylor / Sayensị Kwa ụbọchị: Nje bacteria nwere ike inyere aka belata usoro ịka nká otu ụbọchị.
7. Mkpuchi Azụmahịa nke itinye ego atụmatụ L'Oréal na PAM²L — Jing Daily (Ọktoba 2026): L'Oréal na-enweta òkè 7.13% na teknụzụ ihe ọkụkụ Shenzhen nke Pam²L.
8.Ndekọ Ikpo Okwu nke Venture & Biomaterials maka PAM²L — Dealroom.co (Nọvemba 2026): L'Oréal na Walgreens kwadoro ụlọ ọrụ mmepụta ihe ndị dị na China PAM2L maka nde dollar 30.
9. Ọmụmụ Ihe Nlekọta Ahụike na Pro-Xylane (Hydroxypropyl Tetrahydropyrantriol) — PubMed Central (
PMC12871497): Ojiji nke Usoro Nwere Hydroxypropyl Tetrahydropyrantriol (HPT) na Niacinamide (NAM).10. Ntinye aka nke ihe eji achọ mma nke onwe ya maka Pro-Xylane — Akwụkwọ ọkọwa okwu Paula's Choice Ingredient: Hydroxypropyl Tetrahydropyrantriol.
Disclaimer
Disclaimer: Edepụtara akụkọ a naanị maka ebumnuche nyocha ozi, agụmakwụkwọ, na ụlọ ọrụ, ọ bụghịkwa ndụmọdụ nlekọta akpụkpọ ahụ ọkachamara, ahụike, ma ọ bụ ọkachamara. Ntụnyere arụmọrụ e hotara ebe a - gụnyere usoro nhazi collagen nke ụdị 4x nke hydrolyzed sodium colanate ma e jiri ya tụnyere Pro-Xylane - sitere na ya. in-vitro nyocha mkpụrụ ndụ (anwalere na2 mg/mL) na obere ọmụmụ ihe gbasara ahụike nke ekpughere na ntinye akwụkwọ ikike patent ebipụtara (CN118593537A,WO2025166972A1N'ihi mgbagwoju anya nke ihe mgbochi corneum stratum mmadụ, njupụta usoro emechara, na sistemụ nnyefe, in-vitro Nsonaazụ ụlọ nyocha adịghị ka arụmọrụ ahụike nke ihe ịchọ mma e ji akpụkpọ ahụ mee. Ndị nwere akpụkpọ ahụ dị nro ma ọ bụ ọrịa akpụkpọ ahụ dịbu adị kwesịrị ịgakwuru dọkịta akpụkpọ ahụ nke ụlọ ọrụ kwadoro tupu ha ewebata ihe ọhụrụ na-arụ ọrụ. E dekọrọ akụkọ a n'onwe ya site na ndekọ ikike ọha, akwụkwọ nyochara ndị ọgbọ, na ngosipụta ihe ngosi azụmaahịa, na-enweghị nkwado ego ma ọ bụ nkwado sitere na L'Oréal, PAM²L (Shenzhen Boyin Biotechnology), ma ọ bụ ụlọ ọrụ ọ bụla metụtara ya.
