Ka ọnụ ọgụgụ ndị mmadụ n'ụwa niile na-akawanye nká, nsogbu ịka nká akpụkpọ anụ na-eji nwayọọ nwayọọ na-abụ isi ihe na-elekwasị anya maka mmepe ngwaahịa nlekọta anụ ahụ n'ọdịnihu.
N'ihi ya, ma a mma Ngwakọta nwere ike inye ọrụ mgbochi siri ike na akpụkpọ ahụ aghọwo ihe ịma aka kachasị mkpa n'ọhịa nlekọta anụ ahụ. Kedu ka esi emepụta ihe ọhụrụ iji kwalite ikike mgbochi ịka nká nke akpụkpọ ahụ? Ndị ọkà mmụta sayensị achọpụtala na vitamin C (VC) nwere ike ọ bụghị naanị ịrụ ọrụ ọdịnala ya kamakwa ọ na-akwalite ịgbatị epidermal iji kwalite ikike mgbochi akpụkpọ ahụ.
A maara nke ọma na ihe ịrịba ama nke ịka nká gụnyere epidermal thinning, mbelata cell proliferation, nke emesia na-eduga na akọrọ akpụkpọ, uche, na ezi ahịrị. Nke a pụtara na ọ bụrụ na a ihe nlekọta anụ ahụ nwere ike ibelata nsogbu nke ịcha akpụkpọ ahụ, ọ nwere ike inye aka nke ukwuu na mgbochi ịka nká.
Ọmụmụ ihe ọhụrụ na VC: Ọ nwere ike deeghachi mkpụrụ ndụ Epidermal n'ezie
Ruo ogologo oge, Vitamin C (Ascorbic Acid, VC), ngwa ọdịnala amaara ama, ejirila arụmọrụ ya dabere na mpaghara abụọ a kpochapụrụ: ịcha ọcha na nchekwa antioxidant.
Otú ọ dị, nnyocha e mere site na Tokyo Metropolitan Institute of Gerontology (TMIG) na Japan na-atụghị anya ya ekpughere usoro omimi nke VC na ngalaba mgbochi ịka nká. Nchọpụta a, nke e bipụtara n'akwụkwọ akụkọ nwere ikike Investigative Dermatology, na-ekpughe na VC nwere ike ịkwalite ngwa ngwa epidermal site na usoro epigenetic kpọmkwem, si otú ahụ na-emeziwanye ihe nhazi nhazi na arụ ọrụ mgbochi nke ịka nká kpatara.
Ọmụmụ ihe a, nke Tokyo Metropolitan Institute of Gerontology (TMIG) bipụtara na Nyocha gbasara akpụkpọ anụ, na-enye nkọwa gbasara ọnụọgụgụ.
| egosi | Otu ọgwụgwọ nnwale | Oge mgbanwe mgbanwe | Isi Nchọta ọnụọgụgụ |
| Ọkpụrụkpụ Epidermal | 1.0 mm ma ọ bụ 0.1 mM VC (nnu sodium) | Mgbe 7 Days | A hụrụ mmụba dị ukwuu na ọkpụrụkpụ nke oyi akwa epidermal. |
| Ọkpụrụkpụ Epidermal | 1.0 mm ma ọ bụ 0.1 mM VC (nnu sodium) | Mgbe 14 Days | Epidermis gara n'ihu na-arị elu, ebe stratum corneum (oke oyi akwa) dị ntakịrị, na-egosi na VC kwalitere ntụgharị cell. |
| Ọrụ Mgbasa Cell | 1.0 mm ma ọ bụ 0.1 mM VC (nnu sodium) | 7 na 14 ụbọchị | The ọnụ ọgụgụ nke Ki-67 mkpụrụ ndụ dị mma (akara mmụba) mụbara nke ukwuu, na-atụ aro na-abawanye ọrụ proliferative nke keratinocytes. |
Kedu ka o si enweta nke a? N'izo aka nyocha nke 2025 kachasị ọhụrụ, edemede a na-enye nyocha miri emi nke akụkụ ọzọ nke vitamin C.
Usoro mgbanwe mgbanwe nke VC n'ịkwalite Mgbasa Epidermal: DNA Demethylation
Ihe ọhụrụ nke ọmụmụ TMIG a dabere na nkwenye mbụ ya na VC nwere ike nweta "mmezigharị ime ụlọ" nke usoro akpụkpọ ahụ ozugbo site na nhazi usoro. Enwere ike ịchịkọta ụkpụrụ ya n'ụzọ atọ:
1. Nnwale nnwale: Nrụpụta n'ụdị n'ụdị Epidermal 3D
Ndị otu nyocha TMIG were ihe nlere anya nke mmadụ 3D nke na-eme ka nhazi nke ezigbo akpụkpọ ahụ mmadụ.
Ndị nchọpụta ahụ webatara VC na ntinye nke 1.0 mM na 0.1 mM n'ime ihe nlereanya-ọkwa dị nso na ihe nwere ike ibuga na epidermis site na mgbasa ọbara. Nsonaazụ nnwale ahụ gosipụtara na VC kwalitere oke iwe nke epidermal. Ọzọkwa, mgbe ụbọchị 7 gachara, ọkpụrụkpụ nke oyi akwa epidermal na-abawanye nke ọma.
Mgbe nnwale ahụ gara n'ihu ruo ụbọchị 14, mkpụrụ ndụ epidermal dị n'ime na-abawanye ụba, ọnụ ọgụgụ nke akara mmụba (Ki-67 positive cell) na-abawanye nke ukwuu, na-egosi n'ụzọ doro anya na VC kpalitere mmụba na-arụ ọrụ nke keratinocytes.
2. Usoro ihe omimi: TET Enzymes na mmetụta "Gene Switch".
Ọmụmụ usoro ihe omimi nke omimi kpughere na VC na-arụ ọrụ mkpụrụ ndụ ihe nketa mkpụrụ ndụ "gbachiri nkịtị" na mbụ site n'ịkwalite DNA demethylation.
N'ụzọ dị mkpa, Vitamin C na-arụ ọrụ dị ka onye na-akwado ezinụlọ TET (translocation iri na iri na otu) nke enzymes, na-akwado ọrụ ha. N'okwu ndị nkịtị, enzyme TET na-eme dị ka "nchịcha" na-ewepụ otu methyl na DNA.
N'ime nnwale ahụ, ndị nchọpụta chọpụtara ihe karịrị mpaghara 10,000 demethylated wee chọpụta mmụba dị ukwuu na ọkwa ngosipụta nke mkpụrụ ndụ ihe nketa iri na abụọ metụtara mmụba cell na mmegharị DNA. Okwu ụfọdụ n'ime mkpụrụ ndụ ihe nketa ndị a mụbara ọbụna site na 1.6 ruo 75.2 ugboro. Mgbe ndị nyocha ahụ jiri TET enzyme inhibitor, VC na-ebute mmetụta proliferative gbanwere nke ukwuu.
3. Mgbakwunye arụmọrụ: VC na-agbanwe site na "Nchekwa Mpụga" gaa na "Mgbanwe nke Ime"
Nchọpụta a na-agbatị mkpa nlekọta anụ ahụ VC site na nchacha ọdịnala nke radicals efu ruo "Mgbanwe nke ime." Ọ nwere ike ime ka akpụkpọ ahụ nwee ike iguzogide mkpali ndị dị n'èzí ma na-ejigide mmiri site na ịba ụba epidermal.
Ọzọkwa, ọ nwere ike ịgbalite uto cell ozugbo, na-enye ikike mweghachi dị omimi maka akpụkpọ ahụ mebiri emebi.
Mmetụta Ọdịnihu maka ụlọ ọrụ ịchọ mma: Ịbanye n'oge "Ihe mgbochi Mwube" maka VC
Echiche ọdịnala nwere ike wereworị VC dị ka ihe a na-ahụkarị ihe nlekọta anụ ahụ. Otú ọ dị, ọganihu a na-enye mkpali mgbanwe maka mmepe nke VC na ihe nlekọta anụ ahụ.
Ndị na-ahụ maka ụlọ ọrụ kwenyere n'ọtụtụ ebe na a ga-ebuli ọkwa VC ka ọ bụrụ "Ihe Na-arụ Ọrụ Maka Mwube Skin Barrier."
Otu ọkachamara n'ihe gbasara ụlọ ọrụ kwuru, sị: “Ihe ọmụmụ a pụtara bụ n'iwepụta echiche iji gbanwee ọdịnihu nke mkpụrụ ndụ sesescent na ọkwa mkpụrụ ndụ ihe nketa. ọdịnihu mgbochi ịka nká formulations, anyị nwere ike iji VC megharịa mkpụrụ ndụ ịka nká ma weghachi ikike nrụpụta ebumpụta ụwa ha."
Ọdịnihu omume maka mgbochi ịka nká formulations bụ ijiwanye mmetụta epigenetic nke VC, yana teknụzụ ndị ọzọ na-eme ka ọ dịkwuo mma, iji hụ na VC rutere n'ime epidermis miri emi iji rụọ ọrụ pro-proliferative.
Ọmụmụ ihe na-egosi na ebe ọ bụ na mgbanwe epigenetic na-agbanwe agbanwe, mgbanwe epigenetic na-eme ka VC na-enye nghọta ọhụrụ n'ime usoro ọgwụgwọ ọgwụgwọ.
Oke dị mkpa na Outlook
Ndị otu nyocha ahụ kwukwara na n'agbanyeghị nsonaazụ na-agba ume, enweghị ike ka dị.
Dịka ọmụmaatụ, na nnwale a, ndị nchọpụta jiri nnu sodium VC zere mgbanwe pH kpatara. Na mgbakwunye, iji wepụ ihe ndị na-agbagwoju anya, ha lekwasịrị anya naanị na ndegharị mkpụrụ ndụ ihe nketa karịa ọkwa protein.
Otú ọ dị, o doro anya na site na nyocha ndị ọzọ, jikọtara ya na nyocha nke ihe ndị ọzọ epigenetic dị ka mgbanwe nke histone, Vitamin C dị njikere n'ezie ịghọta ọrụ mgbanwe ya nke "imezigharị ime ụlọ" na ngwaahịa mgbochi ịka nká.
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